期刊
IMMUNOLOGY AND CELL BIOLOGY
卷 89, 期 3, 页码 408-416出版社
WILEY
DOI: 10.1038/icb.2010.151
关键词
Epstein-Barr virus; HIV; dengue virus; natural killer cells; T cells; human vaccination
资金
- German Research Society (DFG)
- Croucher Foundation
- National Cancer Institute [R01CA108609, R01CA101741]
- Foundation for the National Institutes of Health
- Swiss National Science Foundation [310030_126995]
- Sassella Foundation
- Swiss National Science Foundation (SNF) [310030_126995] Funding Source: Swiss National Science Foundation (SNF)
Many pathogens relevant to human disease do not infect other animal species. Therefore, animal models that reconstitute or harbor human tissues are explored as hosts for these. In this review, we will summarize recent advances to utilize mice with human immune system components, reconstituted from hematopoietic progenitor cells in vivo. Such mice can be used to study human pathogens that replicate in leukocytes. In addition to studying the replication of these pathogens, the reconstituted human immune system components can also be analyzed for initiating immune responses and control against these infections. Moreover, these new animal models of human infectious disease should replicate the reactivity of the human immune system to vaccine candidates and, especially, the adjuvants contained in them, more faithfully. Immunology and Cell Biology (2011) 89, 408-416; doi:10.1038/icb.2010.151; published online 8 February 2011
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