期刊
IMMUNOLOGY AND CELL BIOLOGY
卷 89, 期 3, 页码 346-351出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/icb.2010.137
关键词
regulatory T cells; FoxP3; human; autoimmunity; self-tolerance
资金
- Ministry of Education, Sports and Culture of Japan
- Association Lupus France
- SNFMI
- Fondation ARTHRITIS Courtin
Human regulatory T cells (Tregs) expressing the transcription factor FoxP3 play indispensable roles for the maintenance of immunological self-tolerance and immune homeostasis. In this review, we discuss immunological characteristics of human FoxP3(+) Tregs and to what extent they are similar to or different from the murine counterparts. We also discuss important issues that remain to be addressed in the field to better understand the pathophysiology of autoimmune disease and to build solid basis for immunotherapies targeting FoxP3(+) Tregs. Immunology and Cell Biology (2011) 89, 346-351; doi:10.1038/icb.2010.137; published online 8 February 2011
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