期刊
IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA
卷 34, 期 4, 页码 785-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.iac.2014.07.004
关键词
Mitochondria; Asthma; Bioenergetics; Reactive oxygen species; Metabolic syndrome; Arginine; Statin; Metformin
资金
- Lady Tata Memorial Trust [GAP63]
- Council of Scientific and Industrial Research [MLP5502]
- National Institutes of Health [HL088029, HL056470]
Multiple studies have determined that obesity increases asthma risk or severity. Metabolic changes of obesity, such as diabetes or insulin resistance, are associated with asthma and poorer lung function. Insulin resistance is also found to increase asthma risk independent of body mass. Conversely, asthma is associated with abnormal glucose and lipid metabolism, insulin resistance, and obesity. Here we review our current understanding of how dietary and lifestyle factors lead to changes in mitochondrial metabolism and cellular bioenergetics, inducing various components of the cardiometabolic syndrome and airway disease.
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