Mast Cell-Restricted Tetramer-Forming Tryptases and Their Beneficial Roles in Hemostasis and Blood Coagulation

Tetramer-forming tryptase (hTryptase-beta) was recently discovered to have a prominent role in preventing the internal accumulation of life-threatening fibrin deposits and fibrin-platelet clots. The anticoagulant activity of hTryptase-beta is an explanation for the presence of hemorrhagic disorders in some patients with anaphylaxis or mastocytosis. The fragments of hFibrinogen formed by the proteolysis of this prominent protein by hTryptase-beta could be used as biomarkers in the blood and/or urine for the identification and monitoring of patients with mast cell-dependent disorders. Recombinant hTryptase-beta has potential to be used in clinical settings where it is desirable to inhibit blood coagulation.