期刊
IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA
卷 34, 期 2, 页码 219-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.iac.2014.01.002
关键词
Mastocytosis; KIT mutations; KIT signaling; KIT trafficking; KIT inhibitors
资金
- Division of Intramural Research of NIAID within the National Institutes of Health
In-this review, the authors discuss common gain-of-function mutations in the stem cell factor receptor KIT found in mast cell proliferation disorders and summarize the current understanding of the molecular mechanisms by which these transforming mutations may affect KIT structure and function leading to altered downstream signaling and cellular transformation. Drugs targeting KIT have shown mixed success in the treatment of mastocytosis and other hyperproliferative diseases. A brief overview of the most common KIT inhibitors currently used, the reasons for the varied clinical results of such inhibitors and a discussion of potential new strategies are provided.
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