期刊
IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA
卷 28, 期 4, 页码 803-819出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.iac.2008.06.006
关键词
Immunoglobulin; Intravenous; Pharmacokinetics; Subcutaneous
This article reviews pharmacokinetic studies of IgG administration by intravenous and subcutaneous routes. Intravenous immunoglobulin pharmacokinetics have been studied during replacement therapy for primary and secondary immunodeficiencies and other special circumstances (eg, infection prophylaxis in neonates). Subcutaneous immunoglobulin pharmacokinetics have been studied only during replacement therapy for primary immunodeficiency. Published studies vary greatly with respect to the nature of the patients studied, dose regimens, sampling schedules, and pharmacokinetic models, making comparisons difficult. With either route of administration, there is large variation in individual IgG elimination rates. Periodic measurement of serum IgG concentration is critical to monitor the adequacy of replacement during therapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据