期刊
IMMUNOLOGY
卷 155, 期 4, 页码 435-445出版社
WILEY
DOI: 10.1111/imm.12995
关键词
absent in melanoma 2-like receptors; inflammasome; killer-cell immunoglobulin-like receptor; nucleotide-binding oligomerization domain-like receptors; retinoic acid-inducible gene-I-like receptors; signalosome
类别
Formation of supramolecular assemblies appears to be a general mechanism in immune signalling pathways. These supramolecular assemblies appear to form through a nucleated polymerization mechanism. This review examines selected immune signalling pathways that involve supramolecular assemblies, describes the concepts of protein polymerization, and discusses how those concepts of protein polymerization implicate new elegant ways for signal amplification, setting threshold and noise reduction in these pathways.
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