期刊
IMMUNOLOGY
卷 142, 期 1, 页码 39-45出版社
WILEY-BLACKWELL
DOI: 10.1111/imm.12228
关键词
differentiation; vitamin A; dendritic cell; mucosa
类别
资金
- Dutch Scientific Research program (NWO grant) [836.08.003]
Vitamin A and its active metabolite retinoic acid are essential for the development and function of many tissues including the immune system. The induction of mucosal homing receptors on T and B cells by mucosal dendritic cells (DC) depends on the presence of vitamin A. Recent studies indicate that also the differentiation of CD11b(+) DC subsets in the mucosa as well as the spleen depend on vitamin A signalling. As CD11b(+) DC subsets exert non-redundant functions in anti-bacterial and anti-fungal immune responses, defects in CD11b(+) DC differentiation will contribute to the clinical problems observed during vitamin A deficiency.
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