期刊
IMMUNOLOGY
卷 143, 期 2, 页码 164-173出版社
WILEY-BLACKWELL
DOI: 10.1111/imm.12298
关键词
dendritic cells; experimental autoimmune encephalomyelitis; neuroinflammation; Plasmodium extracts
类别
资金
- Sao Paulo Funding Agency (FAPESP) [2011/17965-3]
- FAPESP [2011/13191-3, 2012/08303-0, 2013/01401-9, 2012/22131-7]
- CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior)
Dendritic cells (DCs) are professional antigen-presenting cells specifically targeted during Plasmodium infection. Upon infection, DCs show impaired antigen presentation and T-cell activation abilities. In this study, we aimed to evaluate whether cellular extracts obtained from Plasmodium berghei-infected erythrocytes (PbX) modulate DCs phenotypically and functionally and the potential therapeutic usage of PbX-modulated DCs in the control of experimental autoimmune encephalomyelitis (EAE, the mouse model for human multiple sclerosis). We found that PbX-treated DCs have impaired maturation and stimulated the generation of regulatory T cells when cultured with naive T lymphocytes in vitro. When adoptively transferred to C57BL/6 mice the EAE severity was reduced. Disease amelioration correlated with a diminished infiltration of cytokine-producing T cells in the central nervous system as well as the suppression of encephalitogenic T cells. Our study shows that extracts obtained from P. berghei-infected erythrocytes modulate DCs towards an immunosuppressive phenotype. In addition, the adoptive transfer of PbX-modulated DCs was able to ameliorate EAE development through the suppression of specific cellular immune responses towards neuro-antigens. To our knowledge, this is the first study to present evidence that DCs treated with P. berghei extracts are able to control autoimmune neuroinflammation.
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