期刊
IMMUNOLOGY
卷 135, 期 4, 页码 268-275出版社
WILEY
DOI: 10.1111/j.1365-2567.2011.03549.x
关键词
adaptor proteins; cytoskeleton; inside-out signalling; integrin activation; outside-in signalling
类别
资金
- Ministry of Science and Technology of China [2011CB505005, 2012CB910800]
- National Natural Science Foundation of China [31070778]
- Chinese Academy of Sciences
- Shanghai Science and Technology Committee [11PJ1410700]
Integrins not only mediate cellcell and cellextracellular matrix adhesion, but also affect the multitude of signal transduction cascades in control of cell survival, proliferation, differentiation and organ development. Mutations in integrins or the major effectors of integrin signalling pathways cause defective organ development, immunodeficiency, cancer or autoimmune disease. Understanding of the signalling events that drive integrin activation and signalling is therefore crucial to uncover the molecular mechanisms of these diseases. This review discusses the key signalling complexes regulating integrin activation and function in both inside-out and outside-in pathways in T lymphocytes, including kinases, SLP-76, VAV1, ADAP, SKAP-55, RapL, RIAM, Rap1, Talin and Kindlin.
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