期刊
IMMUNOLOGY
卷 138, 期 1, 页码 23-33出版社
WILEY-BLACKWELL
DOI: 10.1111/imm.12007
关键词
Cytokines; Foxp3 regulatory T cells; Gluten; Mucosal immunology; T cells; Type 1 diabetes
类别
资金
- Danish Research Agency [09-059938]
- Danish Diabetes Foundation [77]
- Kirsten og Freddy Johansens Fond
- Grant Agency of the Czech Republic [303/06/1329, 310/09/1640]
- Grant Agency of the Ministry of Health of the Czech Republic [IGA MZ NS/10340-3]
- Institutional Research Concept [AV0Z50200510]
- Institute of Microbiology, v.v.i, Czech Acad. Sci.
Several studies have documented that dietary modifications influence the development of type 1 diabetes. However, little is known about the interplay of dietary components and the penetration of diabetes incidence. In this study we tested if wheat gluten is able to induce differences in the cytokine pattern of Foxp3+ regulatory T cells, as well as Foxp3- T cells, isolated from intestinal mucosal lymphoid tissue and non-mucosal lymphoid compartments in BALB/c mice. The gluten-containing standard diet markedly changed the cytokine expression within Foxp3- T cells, in all lymphoid organs tested, towards a higher expression of pro-inflammatory interferon-? (IFN-?), interleukin-17 (IL-17) and IL-2. In Foxp3+ regulatory T cells, gluten ingestion resulted in a mucosal increase in IL-17 and IL-2 and an overall increase in IFN-? and IL-4. The gluten-free diet induced an anti-inflammatory cytokine profile with higher proportion of transforming growth factor-beta (TGF-beta)+Foxp3- T cells in all tested lymphoid tissues and higher IL-10 expression within non-T cells in spleen, and a tendency towards a mucosal increase in TGF-beta+Foxp3+ regulatory T cells. Our data shows that the gluten-containing standard diet modifies the cytokine pattern of both Foxp3- T cells and Foxp3+ regulatory T cells towards a more inflammatory cytokine profile. This immune profile may contribute to the higher type 1 diabetes incidence associated with gluten intake.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据