期刊
IMMUNOLOGY
卷 134, 期 1, 页码 41-49出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1365-2567.2011.03464.x
关键词
cytokines; cytotoxicity; interleukin-12; memory; natural killer cells
类别
资金
- 115 grant [2008ZX10003-011]
- National Nature Science Foundation of China [30872300]
- National Key Basic Research Programme of China (973) [2007CB512404]
- Specialized Research Fund for the Doctoral Programme of Higher Education of China [20070558213]
- Medical Scientific Research Foundation of Guangdong Province, China [A2009161]
Natural killer (NK) cells are known as innate immune lymphocytes that respond rapidly when challenged by pathogens but little is known about adaptive immune features including memory related to NK cells from human beings. In the present study, we demonstrate for the first time that human NK cells expressing the memory-associated marker CD45RO were persistent in pleural fluid cells (PFCs) from tuberculous patients. CD45RO(+) NK cells produced significantly more interferon-gamma and were more cytotoxic compared with CD45RO(-) NK cells from PFCs when stimulated with interleukin-12 (IL-12). Consistently, IL-12 enhanced the expression of granzyme B, CD69, CD25, NKG2D, IL-12 receptors beta 1 and beta 2 on CD45RO(+) NK cells from PFCs. Our experiments contribute to a better understanding of the NK cells from PFCs and indicate that human CD45RO(+) NK cells from PFCs expressing a 'memory-like' phenotype may have an important role in defending against infection by Mycobacterium tuberculosis.
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