期刊
IMMUNOLOGY
卷 130, 期 2, 页码 158-165出版社
WILEY
DOI: 10.1111/j.1365-2567.2010.03278.x
关键词
fugetaxis; homing receptors; memory T cells; T-cell homing; trafficking
类别
资金
- British Heart Foundation [RG/09/002]
- MRC [G0901084] Funding Source: UKRI
- British Heart Foundation [RG/09/002/26425] Funding Source: researchfish
- Medical Research Council [G0901084] Funding Source: researchfish
P>The immune system is unique in representing a network of interacting cells of enormous complexity and yet being based on single cells travelling around the body. The development of effective and regulated immunity relies upon co-ordinated migration of each cellular component, which is regulated by diverse signals provided by the tissue. Co-ordinated migration is particularly relevant to the recirculation of primed T cells, which, while performing continuous immune surveillance, need to promptly localize to antigenic sites, reside for a time sufficient to carry out their effector function and then efficiently leave the tissue to avoid bystander damage. Recent advances that have helped to clarify a number of key molecular mechanisms underlying the complexity and efficiency of memory T-cell trafficking, including antigen-dependent T-cell trafficking, the regulation of T-cell motility by costimulatory molecules, T-cell migration out of target tissue and fugetaxis, are reviewed in this article.
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