期刊
IMMUNOLOGY
卷 125, 期 1, 页码 28-37出版社
WILEY
DOI: 10.1111/j.1365-2567.2008.02814.x
关键词
apoptosis; caspase; necrosis; Salmonella typhimurium; systemic infection
类别
资金
- Biotechnology and Biological Sciences Research Council [BBS/B/02266] Funding Source: researchfish
- Biotechnology and Biological Sciences Research Council [BBS/B/02266] Funding Source: Medline
Growth of Salmonella enterica in mammalian tissues results from continuous spread of bacteria to new host cells. Our previous work indicated that infective S. enterica are liberated from host cells via stochastic necrotic burst independently of intracellular bacterial numbers. Here we report that liver phagocytes can undergo apoptotic caspase-3-mediated cell death in vivo, with apoptosis being a rare event, more prevalent in heavily infected cells. The density-dependent apoptotic cell death is likely to constitute an alternative mechanism of bacterial spread as part of a bet-hedging strategy, ensuring an ongoing protective intracellular environment in which some bacteria can grow and persist.
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