期刊
IMMUNOLOGY
卷 123, 期 1, 页码 17-19出版社
WILEY
DOI: 10.1111/j.1365-2567.2007.02774.x
关键词
acetylation; FOXP3; oligomerization; regulatory T cell; transcriptional repression
类别
FOXP3 is an acetylated and phosphorylated protein active in human regulatory T cells and forms oligomers which then associate with an even larger molecular complex. FOXP3 actively regulates transcription by recruiting enzymatic co-repressors and/or co-activators. FOXP3 complex ensembles are dynamically regulated by physiological stimuli such as T-cell receptor, IL-2 and proinflammation cytokine signals. Understanding the post-translational modifications of FOXP3 regulated by diverse signals and the biochemistry and structural chemistry of enzymatic proteins in the FOXP3 complex is critical for therapeutically modulating regulatory T cell function.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据