期刊
IMMUNOLOGICAL REVIEWS
卷 260, 期 1, 页码 76-85出版社
WILEY
DOI: 10.1111/imr.12189
关键词
mucosal immunity; immunoglobulin; class switching; B cells; T cells; dendritic cells; epithelial cells
类别
资金
- US National Institutes of Health [R01 AI57653, U01 AI95613, P01 AI61093, U19 096187]
- ICREA Funding Source: Custom
Complex and diverse communities of bacteria establish mutualistic and symbiotic relationships with the gut after birth. The intestinal immune system responds to bacterial colonization by acquiring a state of hypo-responsiveness against commensals and active readiness against pathogens. The resulting homeostatic balance involves a continuous dialog between the microbiota and lymphocytes with the intermediation of epithelial and dendritic cells. This dialog causes massive production of immunoglobulin A (IgA), a non-inflammatory antibody specialized in mucosal protection. Here, we discuss recent advances on the regulation of intestinal IgA responses and their role in host-microbe interaction.
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