期刊
IMMUNOLOGICAL REVIEWS
卷 252, 期 -, 页码 104-115出版社
WILEY
DOI: 10.1111/imr.12028
关键词
T cells; T-helper cells; transcription factor; differentiation; inflammation
类别
资金
- Public Health Service Grant [AI057459]
CD4(+) T-helper cells regulate immunity and inflammation through the acquisition of potential to secrete specific cytokines. The acquisition of cytokine-secreting potential, in a process termed T-helper cell differentiation, is a response to multiple environmental signals including the cytokine milieu. The most recently defined subset of T-helper cells are termed Th9 and are identified by the potent production of interleukin-9 (IL-9). Given the pleiotropic functions of IL-9, Th9 cells might be involved in pathogen immunity and immune-mediated disease. In this review, I focus on recent developments in understanding the signals that promote Th9 differentiation, the transcription factors that regulate IL-9 expression, and finally the potential roles for Th9 cells in immunity in vivo.
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