相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Regulation of Immune Responses by mTOR
Jonathan D. Powell et al.
ANNUAL REVIEW OF IMMUNOLOGY, VOL 30 (2012)
MST1 mutations in autosomal recessive primary immunodeficiency characterized by defective naive T-cell survival
Nadine T. Nehme et al.
BLOOD (2012)
Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development
Gerritje J. W. van der Windt et al.
IMMUNITY (2012)
Transcription Factor Foxo1 Represses T-bet-Mediated Effector Functions and Promotes Memory CD8+ T Cell Differentiation
Rajesh R. Rao et al.
IMMUNITY (2012)
Protein Energy Malnutrition Impairs Homeostatic Proliferation of Memory CD8 T Cells
Smita S. Iyer et al.
JOURNAL OF IMMUNOLOGY (2012)
Cutting Edge: The Role of IFN-α Receptor and MyD88 Signaling in Induction of IL-15 Expression In Vivo
Sara L. Colpitts et al.
JOURNAL OF IMMUNOLOGY (2012)
TSC1/2 Signaling Complex Is Essential for Peripheral Naive CD8+ T Cell Survival and Homeostasis in Mice
Lianjun Zhang et al.
PLOS ONE (2012)
Skeletal muscle transcriptional coactivator PGC-1α mediates mitochondrial, but not metabolic, changes during calorie restriction
Lydia W. S. Finley et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network
Richard C. Scarpulla
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2011)
IL-7 Engages Multiple Mechanisms to Overcome Chronic Viral Infection and Limit Organ Pathology
Marc Pellegrini et al.
CELL (2011)
Modulation of Longevity and Tissue Homeostasis by the Drosophila PGC-1 Homolog
Michael Rera et al.
CELL METABOLISM (2011)
The Drosophila Estrogen-Related Receptor Directs a Metabolic Switch that Supports Developmental Growth
Jason M. Tennessen et al.
CELL METABOLISM (2011)
Regulation of T-cell survival and mitochondrial homeostasis by TSC1
Thomas F. O'Brien et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2011)
Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress
Kathrin Zaugg et al.
GENES & DEVELOPMENT (2011)
The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation
Ruoning Wang et al.
IMMUNITY (2011)
A Critical Role for STAT3 Transcription Factor Signaling in the Development and Maintenance of Human T Cell Memory
Andrea M. Siegel et al.
IMMUNITY (2011)
Protein Kinase B Controls Transcriptional Programs that Direct Cytotoxic T Cell Fate but Is Dispensable for T Cell Metabolism
Andrew N. Macintyre et al.
IMMUNITY (2011)
An Interleukin-21-Interleukin-10-STAT3 Pathway Is Critical for Functional Maturation of Memory CD8+ T Cells
Weiguo Cui et al.
IMMUNITY (2011)
HIF1α-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells
Lewis Z. Shi et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2011)
Kruppel-Like Factor 2 Is Required for Trafficking but Not Quiescence in Postactivated T Cells
Kensuke Takada et al.
JOURNAL OF IMMUNOLOGY (2011)
The Liver Kinase B1 Is a Central Regulator of T Cell Development, Activation, and Metabolism
Nancie J. MacIver et al.
JOURNAL OF IMMUNOLOGY (2011)
The Tuberous Sclerosis Complex-Mammalian Target of Rapamycin Pathway Maintains the Quiescence and Survival of Naive T Cells
Qi Wu et al.
JOURNAL OF IMMUNOLOGY (2011)
Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets
Ryan D. Michalek et al.
JOURNAL OF IMMUNOLOGY (2011)
Transcription factor Foxp1 exerts essential cell-intrinsic regulation of the quiescence of naive T cells
Xiaoming Feng et al.
NATURE IMMUNOLOGY (2011)
The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function
Kai Yang et al.
NATURE IMMUNOLOGY (2011)
The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2
Greg M. Delgoffe et al.
NATURE IMMUNOLOGY (2011)
mTOR: from growth signal integration to cancer, diabetes and ageing
Roberto Zoncu et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2011)
Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation
Ryan D. Michalek et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Manipulating the Bioenergetics of Alloreactive T Cells Causes Their Selective Apoptosis and Arrests Graft-Versus-Host Disease
Erin Gatza et al.
SCIENCE TRANSLATIONAL MEDICINE (2011)
Metabolism, migration and memory in cytotoxic T cells
David Finlay et al.
NATURE REVIEWS IMMUNOLOGY (2011)
Metabolism in T cell activation and differentiation
Erika L. Pearce
CURRENT OPINION IN IMMUNOLOGY (2010)
LKB1 is essential for the proliferation of T-cell progenitors and mature peripheral T cells
Peter Tamas et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2010)
The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism
Kathryn E. Wellen et al.
GENES & DEVELOPMENT (2010)
Foxo Transcription Factors Control Regulatory T Cell Development and Function
Yann M. Kerdiles et al.
IMMUNITY (2010)
The mTOR Kinase Determines Effector versus Memory CD8+ T Cell Fate by Regulating the Expression of Transcription Factors T-bet and Eomesodermin
Rajesh R. Rao et al.
IMMUNITY (2010)
IL-15 trans-presentation by pulmonary dendritic cells promotes effector CD8 T cell survival during influenza virus infection
Jodi McGill et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2010)
Cutting Edge: Expression of the Transcription Factor E74-Like Factor 4 Is Regulated by the Mammalian Target of Rapamycin Pathway in CD8+ T Cells
Takeshi Yamada et al.
JOURNAL OF IMMUNOLOGY (2010)
Cutting Edge: The Transcription Factor Eomesodermin Enables CD8+ T Cells To Compete for the Memory Cell Niche
Arnob Banerjee et al.
JOURNAL OF IMMUNOLOGY (2010)
Glutamine Uptake and Metabolism Are Coordinately Regulated by ERK/MAPK during T Lymphocyte Activation
Erikka L. Carr et al.
JOURNAL OF IMMUNOLOGY (2010)
Cellular Metabolic Stress: Considering How Cells Respond to Nutrient Excess
Kathryn E. Wellen et al.
MOLECULAR CELL (2010)
Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells
Daisuke Nakada et al.
NATURE (2010)
The Lkb1 metabolic sensor maintains haematopoietic stem cell survival
Sushma Gurumurthy et al.
NATURE (2010)
Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells
Boyi Gan et al.
NATURE (2010)
Differential effects of STAT5 and PI3K/AKT signaling on effector and memory CD8 T-cell survival
Timothy W. Hand et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
AMP-activated Protein Kinase and FoxO Transcription Factors in Dietary Restriction-induced Longevity
Eric L. Greer et al.
INTERNATIONAL SYMPOSIUM ON OLFACTION AND TASTE (2009)
Spare respiratory capacity, oxidative stress and excitotoxicity
David G. Nicholls
BIOCHEMICAL SOCIETY TRANSACTIONS (2009)
The TOR pathway comes of age
Monique N. Stanfel et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2009)
AMP-activated protein kinase pathway: a potential therapeutic target in cardiometabolic disease
Aaron K. F. Wong et al.
CLINICAL SCIENCE (2009)
The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment
Greg M. Delgoffe et al.
IMMUNITY (2009)
mTOR signaling at a glance
Mathieu Laplante et al.
JOURNAL OF CELL SCIENCE (2009)
Bioenergetic analysis of isolated cerebrocortical nerve terminals on a microgram scale: spare respiratory capacity and stochastic mitochondrial failure
Sung W. Choi et al.
JOURNAL OF NEUROCHEMISTRY (2009)
Landscape Analysis of Interactions between Nutrition and Vaccine Responses in Children
Mathilde Savy et al.
JOURNAL OF NUTRITION (2009)
Phosphoinositide (3,4,5)-Triphosphate Binding to Phosphoinositide-Dependent Kinase 1 Regulates a Protein Kinase B/Akt Signaling Threshold That Dictates T-Cell Migration, Not Proliferation
Caryll Waugh et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
Enhancing CD8 T-cell memory by modulating fatty acid metabolism
Erika L. Pearce et al.
NATURE (2009)
mTOR regulates memory CD8 T-cell differentiation
Koichi Araki et al.
NATURE (2009)
Transcription factor ELF4 controls the proliferation and homing of CD8(+) T cells via the Kruppel-like factors KLF4 and KLF2
Takeshi Yamada et al.
NATURE IMMUNOLOGY (2009)
Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor
Yann M. Kerdiles et al.
NATURE IMMUNOLOGY (2009)
Mitochondrial STAT3 Supports Ras-Dependent Oncogenic Transformation
Daniel J. Gough et al.
SCIENCE (2009)
Function of Mitochondrial Stat3 in Cellular Respiration
Joanna Wegrzyn et al.
SCIENCE (2009)
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
Matthew G. Vander Heiden et al.
SCIENCE (2009)
Interdependence of hypoxic and innate immune responses
Victor Nizet et al.
NATURE REVIEWS IMMUNOLOGY (2009)
Dynamic regulation of PGC-1α localization and turnover implicates mitochondrial adaptation in calorie restriction and the stress response
Rozalyn M. Anderson et al.
AGING CELL (2008)
Dendritic cells drive memory CD8 T-cell homeostasis via IL-15 transpresentation
Spencer W. Stonier et al.
BLOOD (2008)
The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation
Ralph J. DeBerardinis et al.
CELL METABOLISM (2008)
Brick by brick: metabolism and tumor cell growth
Ralph J. DeBerardinis et al.
CURRENT OPINION IN GENETICS & DEVELOPMENT (2008)
Advances in measuring cellular bioenergetics using extracellular flux
David A. Ferrick et al.
DRUG DISCOVERY TODAY (2008)
Transcriptional Control of Energy Homeostasis by the Estrogen-Related Receptors
Vincent Giguere
ENDOCRINE REVIEWS (2008)
Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cells
Candace M. Cham et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2008)
Effect of aging, caloric restriction, and uncoupling protein 3 (UCP3) on mitochondrial proton leak in mice
Danny K. Asami et al.
EXPERIMENTAL GERONTOLOGY (2008)
CD36-dependent regulation of muscle FoxO1 and PDK4 in the PPARδ/β-mediated adaptation to metabolic stress
Zaher Nahle et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species
Chong Chen et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2008)
Glucose uptake is limiting in T cell activation and requires CD28-mediated akt-dependent and independent pathways
Sarah R. Jacobs et al.
JOURNAL OF IMMUNOLOGY (2008)
Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival
Nancie J. MacIver et al.
JOURNAL OF LEUKOCYTE BIOLOGY (2008)
Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking
Linda V. Sinclair et al.
NATURE IMMUNOLOGY (2008)
Involvement of estrogen-related receptors in transcriptional response to hypoxia and growth of solid tumors
Ada Ao et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Batf3 Deficiency Reveals a Critical Role for CD8α+ Dendritic Cells in Cytotoxic T Cell Immunity
Kai Hildner et al.
SCIENCE (2008)
Fat Metabolism Links Germline Stem Cells and Longevity in C. elegans
Meng C. Wang et al.
SCIENCE (2008)
ERR alpha: a metabolic function for the oldest orphan
Josep A. Villena et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2008)
Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
Ralph J. DeBerardinis et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Convergence of multiple signaling pathways is required to coordinately up-regulate mtDNA and mitochondrial biogenesis during T cell activation
Anthony D. D'Souza et al.
MITOCHONDRION (2007)
mTOR controls mitochondrial oxidative function through a YY1-PGC-1α transcriptional complex
John T. Cunningham et al.
NATURE (2007)
The mammalian target of rapamycin regulates lipid metabolism in primary cultures of rat hepatocytes
Nicholas F. Brown et al.
METABOLISM-CLINICAL AND EXPERIMENTAL (2007)
AGEMAP: A gene expression database for aging in mice
Jacob M. Zahn et al.
PLOS GENETICS (2007)
Revving the engine: signal transduction fuels T cell activation
Russell G. Jones et al.
IMMUNITY (2007)
Inflammation directs memory precursor and short-lived effector CD8+ T cell fates via the graded expression of T-bet transcription factor
Nikhil S. Joshi et al.
IMMUNITY (2007)
HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation
John D. Gordan et al.
CANCER CELL (2007)
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α
Sibylle Jaeger et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Spare respiratory capacity rather than oxidative stress regulates glutamate excitotoxicity after partial respiratory inhibition of mitochondrial complex I with rotenone
Nagendra Yadava et al.
JOURNAL OF NEUROSCIENCE (2007)
Energy-dependent regulation of cell structure by AMP-activated protein kinase
Jun Hee Lee et al.
NATURE (2007)
HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity
Huafeng Zhang et al.
CANCER CELL (2007)
Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking
Heather L. Wiernan et al.
MOLECULAR BIOLOGY OF THE CELL (2007)
Asymmetric T lymphocyte division in the initiation of adaptive immune responses
John T. Chang et al.
SCIENCE (2007)
Phosphatidylinositol 3-kinase-dependent modulation of carnitine palmitoyltransferase 1A expression regulates lipid metabolism during hematopoietic cell growth
Ralph J. DeBerardinis et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Rapamycin-mediated inhibition of mammalian target of rapamycin in skeletal muscle cells reduces glucose utilization and increases fatty acid oxidation
Ian J. Sipula et al.
METABOLISM-CLINICAL AND EXPERIMENTAL (2006)
Kruppel-like factor 2 regulates thymocyte and T-cell migration
Corey M. Carlson et al.
NATURE (2006)
Differential regulation of T-cell growth by IL-2 and IL-15
Georgina H. Cornish et al.
BLOOD (2006)
A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span
Maria K. Lehtinen et al.
CELL (2006)
HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
I Papandreou et al.
CELL METABOLISM (2006)
Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin
AM Intlekofer et al.
NATURE IMMUNOLOGY (2005)
Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients
M Kaeberlein et al.
SCIENCE (2005)
Fuel feeds function: Energy metabolism and the T-cell response
CJ Fox et al.
NATURE REVIEWS IMMUNOLOGY (2005)
Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis
F Li et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Glucose availability regulates IFN-γ production and p70S6 kinase activation in CD8+ effector T cells
CM Cham et al.
JOURNAL OF IMMUNOLOGY (2005)
Stable activation of phosphatidylinositol 3-kinase in the T cell immunological synapse stimulates Akt signaling to FoxO1 nuclear exclusion and cell growth control
S Fabre et al.
JOURNAL OF IMMUNOLOGY (2005)
The plasticity of aging: Insights from long-lived mutants
C Kenyon
CELL (2005)
Growth factor regulation of autophagy and cell survival in the absence of apoptosis
JJ Lum et al.
CELL (2005)
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
RJ Shaw et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Activation of PI3K is indispensable for interleukin 7-mediated viability, proliferation, glucose use, and growth of T cell acute lymphoblastic leukemia cells
JT Barata et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2004)
Bc16 acts as an amplifier for the generation and proliferative capacity of central memory CD8+ T cells
H Ichii et al.
JOURNAL OF IMMUNOLOGY (2004)
The LKB1 tumor suppressor negatively regulates mTOR signaling
RJ Shaw et al.
CANCER CELL (2004)
Akt stimulates aerobic glycolysis in cancer cells
RL Elstrom et al.
CANCER RESEARCH (2004)
Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway
P Kapahi et al.
CURRENT BIOLOGY (2004)
IDO expression by dendritic cells: Tolerance and tryptophan catabolism
AL Mellor et al.
NATURE REVIEWS IMMUNOLOGY (2004)
Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells
SM Kaech et al.
NATURE IMMUNOLOGY (2003)
LKB1 is the upstream kinase in the AMP-activated protein kinase cascade
A Woods et al.
CURRENT BIOLOGY (2003)
Forkhead transcription factor FOX01 (FKHR)-dependent induction of PDK4 gene expression in skeletal muscle during energy deprivation
T Furuyama et al.
BIOCHEMICAL JOURNAL (2003)
Activated Akt promotes increased resting T cell size, CD28-independent T cell growth, and development of autoimmunity and lymphoma
JC Rathmell et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2003)
Regulation of quiescence in lymphocytes
I Yusuf et al.
TRENDS IN IMMUNOLOGY (2003)
Lipotoxicity: when tissues overeat
JE Schaffer
CURRENT OPINION IN LIPIDOLOGY (2003)
Insulin and longevity: antidiabetic biguanides as geroprotectors
VN Anisimov et al.
BIOGERONTOLOGY (2003)
MTOR interacts with Raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
DH Kim et al.
CELL (2002)
Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake
AL Edinger et al.
MOLECULAR BIOLOGY OF THE CELL (2002)
Role for Bcl-6 in the generation and maintenance of memory CD8+ T cells
H Ichii et al.
NATURE IMMUNOLOGY (2002)
The CD28 signaling pathway regulates glucose metabolism
KA Frauwirth et al.
IMMUNITY (2002)
Antigen-presenting dendritic cells provide the reducing extracellular microenvironment required for T lymphocyte activation
G Angelini et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Signaling takes a breath - New quantitative perspectives on bioenergetics and signal transduction
S Krauss et al.
IMMUNITY (2001)
IL-7 is critical for homeostatic proliferation and survival of naive T cells
JT Tan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Regulation of translation initiation by FRAP/mTOR
AC Gingras et al.
GENES & DEVELOPMENT (2001)
Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo
KS Schluns et al.
NATURE IMMUNOLOGY (2000)
Fatty acid import into mitochondria
J Kerner et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2000)
In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability
JC Rathmell et al.
MOLECULAR CELL (2000)