相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。mTOR Signaling in Growth Control and Disease
Mathieu Laplante et al.
CELL (2012)
Connecting mTORC1 signaling to SREBP-1 activation
Inan Bakan et al.
CURRENT OPINION IN LIPIDOLOGY (2012)
Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development
Gerritje J. W. van der Windt et al.
IMMUNITY (2012)
Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia
Keunwook Lee et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2012)
New Insights on OX40 in the Control of T Cell Immunity and Immune Tolerance In Vivo
Xiang Xiao et al.
JOURNAL OF IMMUNOLOGY (2012)
The translational landscape of mTOR signalling steers cancer initiation and metastasis
Andrew C. Hsieh et al.
NATURE (2012)
How the TCR balances sensitivity and specificity for the recognition of self and pathogens
Gerald P. Morris et al.
NATURE IMMUNOLOGY (2012)
Impaired autophagy due to constitutive mTOR activation sensitizes TSC2-null cells to cell death under stress
Shukie Ng et al.
AUTOPHAGY (2011)
Constitutive reductions in mTOR alter cell size, immune cell development, and antibody production
Shuling Zhang et al.
BLOOD (2011)
Activation of mTORC2 by Association with the Ribosome
Vittoria Zinzalla et al.
CELL (2011)
mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway
Timothy R. Peterson et al.
CELL (2011)
Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1
Eric V. Dang et al.
CELL (2011)
Akt Stimulates Hepatic SREBP1c and Lipogenesis through Parallel mTORC1-Dependent and Independent Pathways
Jessica L. Yecies et al.
CELL METABOLISM (2011)
The many faces of Th17 cells
Anneli Peters et al.
CURRENT OPINION IN IMMUNOLOGY (2011)
Regulation of T-cell survival and mitochondrial homeostasis by TSC1
Thomas F. O'Brien et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2011)
Integrated T-cell receptor and costimulatory signals determine TGF-β-dependent differentiation and maintenance of Foxp3+ regulatory T cells
Leona Gabrysova et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2011)
The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation
Ruoning Wang et al.
IMMUNITY (2011)
A Central Role for mTOR Kinase in Homeostatic Proliferation Induced CD8+ T Cell Memory and Tumor Immunity
Qingsheng Li et al.
IMMUNITY (2011)
Liver X receptor (LXR) mediates negative regulation of mouse and human Th17 differentiation
Guoliang Cui et al.
JOURNAL OF CLINICAL INVESTIGATION (2011)
HIF1α-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells
Lewis Z. Shi et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2011)
Autophagy Regulates Endoplasmic Reticulum Homeostasis and Calcium Mobilization in T Lymphocytes
Wei Jia et al.
JOURNAL OF IMMUNOLOGY (2011)
Peroxisome Proliferator-Activated Receptor γ Is Required for CD4+ T Cell-Mediated Lymphopenia-Associated Autoimmunity
William J. Housley et al.
JOURNAL OF IMMUNOLOGY (2011)
Temporal Regulation of Intracellular Organelle Homeostasis in T Lymphocytes by Autophagy
Wei Jia et al.
JOURNAL OF IMMUNOLOGY (2011)
OX40 Complexes with Phosphoinositide 3-Kinase and Protein Kinase B (PKB) To Augment TCR-Dependent PKB Signaling
Takanori So et al.
JOURNAL OF IMMUNOLOGY (2011)
The Tuberous Sclerosis Complex-Mammalian Target of Rapamycin Pathway Maintains the Quiescence and Survival of Naive T Cells
Qi Wu et al.
JOURNAL OF IMMUNOLOGY (2011)
Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets
Ryan D. Michalek et al.
JOURNAL OF IMMUNOLOGY (2011)
AP-1 Regulates Cyclin D1 and c-MYC Transcription in an AKT-Dependent Manner in Response to mTOR Inhibition: Role of AIP4/Itch-Mediated JUNB Degradation
Raffi Vartanian et al.
MOLECULAR CANCER RESEARCH (2011)
The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function
Kai Yang et al.
NATURE IMMUNOLOGY (2011)
The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2
Greg M. Delgoffe et al.
NATURE IMMUNOLOGY (2011)
Characterization of the Metabolic Phenotype of Rapamycin-Treated CD8+ T Cells with Augmented Ability to Generate Long-Lasting Memory Cells
Shan He et al.
PLOS ONE (2011)
Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth
Qian Sun et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
ER Stress Inhibits mTORC2 and Akt Signaling Through GSK-3β-Mediated Phosphorylation of Rictor
Chien-Hung Chen et al.
SCIENCE SIGNALING (2011)
Manipulating the Bioenergetics of Alloreactive T Cells Causes Their Selective Apoptosis and Arrests Graft-Versus-Host Disease
Erin Gatza et al.
SCIENCE TRANSLATIONAL MEDICINE (2011)
Induction of T cell anergy: integration of environmental cues and infectious tolerance
Pascal Chappert et al.
CURRENT OPINION IN IMMUNOLOGY (2010)
LKB1 is essential for the proliferation of T-cell progenitors and mature peripheral T cells
Peter Tamas et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2010)
Mammalian Target of Rapamycin Controls Dendritic Cell Development Downstream of Flt3 Ligand Signaling
Taheri Sathaliyawala et al.
IMMUNITY (2010)
An Oscillatory Switch in mTOR Kinase Activity Sets Regulatory T Cell Responsiveness
Claudio Procaccini et al.
IMMUNITY (2010)
The Mammalian Target of Rapamycin: Linking T Cell Differentiation, Function, and Metabolism
Jonathan D. Powell et al.
IMMUNITY (2010)
Mammalian Target of Rapamycin Protein Complex 2 Regulates Differentiation of Th1 and Th2 Cell Subsets via Distinct Signaling Pathways
Keunwook Lee et al.
IMMUNITY (2010)
The mTOR Kinase Determines Effector versus Memory CD8+ T Cell Fate by Regulating the Expression of Transcription Factors T-bet and Eomesodermin
Rajesh R. Rao et al.
IMMUNITY (2010)
TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo
Rachel A. Gottschalk et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2010)
Peroxisome Proliferator-Activated Receptor a and g Agonists Together with TGF-β Convert Human CD4+CD25- T Cells into Functional Foxp3+ Regulatory T Cells
Jin Lei et al.
JOURNAL OF IMMUNOLOGY (2010)
Leptin Modulates the Survival of Autoreactive CD4+ T Cells through the Nutrient/Energy-Sensing Mammalian Target of Rapamycin Signaling Pathway
Mario Galgani et al.
JOURNAL OF IMMUNOLOGY (2010)
Glutamine Uptake and Metabolism Are Coordinately Regulated by ERK/MAPK during T Lymphocyte Activation
Erikka L. Carr et al.
JOURNAL OF IMMUNOLOGY (2010)
Sin1-mTORC2 Suppresses rag and il7r Gene Expression through Akt2 in B Cells
Adam S. Lazorchak et al.
MOLECULAR CELL (2010)
Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1
Katrin Duevel et al.
MOLECULAR CELL (2010)
Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress
Shomit Sengupta et al.
MOLECULAR CELL (2010)
Characterization of the metabolic phenotype of chronically activated lymphocytes
D. R. Wahl et al.
LUPUS (2010)
mTORC1 controls fasting-induced ketogenesis and its modulation by ageing
Shomit Sengupta et al.
NATURE (2010)
The S1P1-mTOR axis directs the reciprocal differentiation of TH1 and Treg cells
Guangwei Liu et al.
NATURE IMMUNOLOGY (2010)
IL-35-mediated induction of a potent regulatory T cell population
Lauren W. Collison et al.
NATURE IMMUNOLOGY (2010)
Duration of antigen receptor signaling determines T-cell tolerance or activation
Shoshana D. Katzman et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
CCL5 promotes proliferation of MCF-7 cells through mTOR-dependent mRNA translation
Thomas T. Murooka et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)
An Amino Acid Shuffle Activates mTORC1
Adiel Cohen et al.
CELL (2009)
Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy
Paul Nicklin et al.
CELL (2009)
Growth controls connect Interactions between c-myc and the tuberous sclerosis complex-mTOR pathway
Emmett V. Schmidt et al.
CELL CYCLE (2009)
Tumor suppressors and cell metabolism: a recipe for cancer growth
Russell G. Jones et al.
GENES & DEVELOPMENT (2009)
Control of Regulatory T Cell Lineage Commitment and Maintenance
Steven Z. Josefowicz et al.
IMMUNITY (2009)
The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment
Greg M. Delgoffe et al.
IMMUNITY (2009)
mTOR: taking cues from the immune microenvironment
Greg M. Delgoffe et al.
IMMUNOLOGY (2009)
Enhanced Interferon-gamma Gene Expression in T Cells and Reduced Ovalbumin-Dependent Lung Eosinophilia in Hypoxia-Inducible Factor-1-alpha-Deficient Mice
Jia Guo et al.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY (2009)
ULK1•ATG13•FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy
Ian G. Ganley et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
mTOR signaling at a glance
Mathieu Laplante et al.
JOURNAL OF CELL SCIENCE (2009)
The nuclear receptor PPARγ selectively inhibits Th17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity
Luisa Klotz et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2009)
PD-L1 regulates the development, maintenance, and function of induced regulatory T cells
Loise M. Francisco et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2009)
Anergic T Cells Are Metabolically Anergic
Yan Zheng et al.
JOURNAL OF IMMUNOLOGY (2009)
Memory-Like CD8+ T Cells Generated during Homeostatic Proliferation Defer to Antigen-Experienced Memory Cells
Kitty P. Cheung et al.
JOURNAL OF IMMUNOLOGY (2009)
Autophagy Is Essential for Mitochondrial Clearance in Mature T Lymphocytes
Heather H. Pua et al.
JOURNAL OF IMMUNOLOGY (2009)
ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery
Chang Hwa Jung et al.
MOLECULAR BIOLOGY OF THE CELL (2009)
Enhancing CD8 T-cell memory by modulating fatty acid metabolism
Erika L. Pearce et al.
NATURE (2009)
mTOR regulates memory CD8 T-cell differentiation
Koichi Araki et al.
NATURE (2009)
The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR
Guangwei Liu et al.
NATURE IMMUNOLOGY (2009)
Dynamics and diversity in autophagy mechanisms: lessons from yeast
Hitoshi Nakatogawa et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)
Insulin Stimulates Adipogenesis through the Akt-TSC2-mTORC1 Pathway
Hui H. Zhang et al.
PLOS ONE (2009)
mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)
Juan M. Garcia-Martinez et al.
BIOCHEMICAL JOURNAL (2008)
Regulation of macroautophagy by mTOR and Beclin 1 complexes
Sophie Pattingre et al.
BIOCHIMIE (2008)
SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth
Thomas Porstmann et al.
CELL METABOLISM (2008)
Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling
Maurice Phillip DeYoung et al.
GENES & DEVELOPMENT (2008)
The TSC-mTOR Signaling Pathway Regulates the Innate Inflammatory Response
Thomas Weichhart et al.
IMMUNITY (2008)
Heterogeneous nuclear ribonucleoprotein A1 regulates cyclin D1 and c-myc internal ribosome entry site function through Akt signaling
Oak D. Jo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells
Sokol Haxhinasto et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2008)
ICOS ligation recruits the p50α PI3K regulatory subunit to the immunological synapse
Camille Fos et al.
JOURNAL OF IMMUNOLOGY (2008)
De novo induction of antigen-specific CD4+CD25+Foxp3+ regulatory T cells in vivo following systemic antigen administration accompanied by blockade of mTOR
Johnthomas Kang et al.
JOURNAL OF LEUKOCYTE BIOLOGY (2008)
AMPK phosphorylation of raptor mediates a metabolic checkpoint
Dana M. Gwinn et al.
MOLECULAR CELL (2008)
Regulation of TORC1 by Rag GTPases in nutrient response
Eunjung Kim et al.
NATURE CELL BIOLOGY (2008)
T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR
Stephan Sauer et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
Yasemin Sancak et al.
SCIENCE (2008)
Differential impact of mammalian target of rapamycin inhibition on CD4(+)CD25(+)Foxp3(+) regulatory T cells compared with conventional CD4(+) T cells
Robert Zeiser et al.
BLOOD (2008)
mTOR controls mitochondrial oxidative function through a YY1-PGC-1α transcriptional complex
John T. Cunningham et al.
NATURE (2007)
The mammalian target of rapamycin regulates lipid metabolism in primary cultures of rat hepatocytes
Nicholas F. Brown et al.
METABOLISM-CLINICAL AND EXPERIMENTAL (2007)
SiRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy
Edmond Y. W. Chan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation
John D. Gordan et al.
CANCER CELL (2007)
Notch-induced T cell development requires phosphoinositide-dependent kinase 1
April P. Kelly et al.
EMBO JOURNAL (2007)
PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding
Lifu Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Peroxisome proliferator-activated receptor γ (PPARγ) and immunoregulation:: Enhancement of regulatory T cells through PPARγ-dependent and -independent mechanisms
Elizabeth A. Wohlfert et al.
JOURNAL OF IMMUNOLOGY (2007)
SREBP in signal transduction: cholesterol metabolism and beyond
Maria T. Bengoechea-Alonso et al.
CURRENT OPINION IN CELL BIOLOGY (2007)
The regulation of AMPK β1, TSC2, and PTEN expression by p53:: Stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways
Zhaohui Feng et al.
CANCER RESEARCH (2007)
Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40
Emilie Vander Haar et al.
NATURE CELL BIOLOGY (2007)
Peroxisome proliferator-activated receptor (PPAR)α expression in T cells mediates gender differences in development of T cell-mediated autoimmunity
Shannon E. Dunn et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2007)
A role for mammalian target of rapamycin in regulating T cell activation versus anergy
Yan Zheng et al.
JOURNAL OF IMMUNOLOGY (2007)
A critical role for the autophagy gene Atg5 in T cell survival and proliferation
Heather H. Pua et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2007)
Anti-OX40 stimulation in vivo enhances CD8(+) memory T cell survival and significantly increases recall responses
Carl E. Ruby et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2007)
Peroxisome proliferator-activated receptor gamma is required for regulatory CD4(+) T cell-mediated protection against colitis
Raquel Hontecillas et al.
JOURNAL OF IMMUNOLOGY (2007)
Rapamycin-conditioned dendritic cells are poor stimulators of allogeneic CD4(+) T cells, but enrich for antigen-specific Foxp3(+) T regulatory cells and promote organ transplant tolerance
Heth R. Turnquist et al.
JOURNAL OF IMMUNOLOGY (2007)
Rapamycin-mediated inhibition of mammalian target of rapamycin in skeletal muscle cells reduces glucose utilization and increases fatty acid oxidation
Ian J. Sipula et al.
METABOLISM-CLINICAL AND EXPERIMENTAL (2006)
Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCα but not S6K1
David A. Guertin et al.
DEVELOPMENTAL CELL (2006)
The roles of intracellular protein-degradation pathways in neurodegeneration
David C. Rubinsztein
NATURE (2006)
Autophagy is induced in CD4+ T cells and important for the growth factor-withdrawal cell death
Changyou Li et al.
JOURNAL OF IMMUNOLOGY (2006)
Cutting edge:: Hypoxia-inducible factor 1α and its activation-inducible short isoform I.1 negatively regulate functions of CD4+ and CD8+ T lymphocytes
Dmitriy Lukashev et al.
JOURNAL OF IMMUNOLOGY (2006)
Tristetraprolin regulates Cyclin D1 and c-myc mRNA stability in response to rapamycin in an Akt-dependent manner via p38 MAPK signaling
M. Marderosian et al.
ONCOGENE (2006)
The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity
Stefan M. Schieke et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Pentose phosphates in nucleoside interconversion and catabolism
MG Tozzi et al.
FEBS JOURNAL (2006)
Sorting out the roles of PPARα in energy metabolism and vascular horneostasis
P Lefebvre et al.
JOURNAL OF CLINICAL INVESTIGATION (2006)
HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
JW Kim et al.
CELL METABOLISM (2006)
Prolonged TCR/CD28 engagement drives IL-2-independent T cell clonal expansion through signaling mediated by the mammalian target of rapamycin
Sara Colombetti et al.
JOURNAL OF IMMUNOLOGY (2006)
Expanding the effector CD4 T-cell repertoire: the Th17 lineage
Laurie E. Harrington et al.
CURRENT OPINION IN IMMUNOLOGY (2006)
CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms
RV Parry et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Fuel feeds function: Energy metabolism and the T-cell response
CJ Fox et al.
NATURE REVIEWS IMMUNOLOGY (2005)
Sequence motifs in IL-4Rα mediating cell-cycle progression of primary lymphocytes
LM Stephenson et al.
JOURNAL OF IMMUNOLOGY (2005)
Regulation of mTOR and cell growth in response to energy stress by REDD1
A Sofer et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
TCR engagement increases hypoxia-inducible factor-1α protein synthesis via rapamycin-sensitive pathway under hypoxic conditions in human peripheral T cells
H Nakamura et al.
JOURNAL OF IMMUNOLOGY (2005)
Peroxisome proliferator-activated receptor α interacts with high affinity and is conformationally responsive to endogenous ligands
HA Hostetler et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Regulation of hypoxia-inducible factor (HIF)-1 activity and expression of HIF hydroxylases in response to insulin-like growth factor I
C Treins et al.
MOLECULAR ENDOCRINOLOGY (2005)
AMP-activated protein kinase induces a p53-dependent metabolic checkpoint
RG Jones et al.
MOLECULAR CELL (2005)
Cyclin D1 and c-myc internal ribosome entry site (IRES)-dependent translation is regulated by AKT activity and enhanced by rapamycin through a p38 MAPK- and ERK-dependent pathway
YJ Shi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolism
M Ciofani et al.
NATURE IMMUNOLOGY (2005)
Regulation of T lymphocyte metabolism
KA Frauwirth et al.
JOURNAL OF IMMUNOLOGY (2004)
Activation of PI3K is indispensable for interleukin 7-mediated viability, proliferation, glucose use, and growth of T cell acute lymphoblastic leukemia cells
JT Barata et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2004)
The life cycle of C-myc - From synthesis to degradation
RC Sears
CELL CYCLE (2004)
Activation of PPAR γ and δ by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease
J Bassaganya-Riera et al.
GASTROENTEROLOGY (2004)
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex
J Brugarolas et al.
GENES & DEVELOPMENT (2004)
Repression of IFN-γ expression by peroxisome proliferator-activated receptor γ
R Cunard et al.
JOURNAL OF IMMUNOLOGY (2004)
Regulation of peroxisome proliferator-activated receptor-γ activity by mammalian target of rapamycin and amino acids in adipogenesis
JE Kim et al.
DIABETES (2004)
mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways
PK Majumder et al.
NATURE MEDICINE (2004)
LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation
Y Kabeya et al.
JOURNAL OF CELL SCIENCE (2004)
Myc pathways provoking cell suicide and cancer
JA Nilsson et al.
ONCOGENE (2003)
Inhibition of interleukin-4 production in CD4+ T cells by peroxisome proliferator-activated receptor-γ (PPAR-γ) ligands:: Involvement of physical association between PPAR-γ and the nuclear factor of activated T cells transcription factor
SW Chung et al.
MOLECULAR PHARMACOLOGY (2003)
Peroxisome proliferator-activated receptor 7 ligands attenuate immunological symptoms of experimental allergic asthma
C Mueller et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2003)
Anti-tumor T cell response and protective immunity in mice that received sublethal irradiation and immune reconstitution
J Ma et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2003)
Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins
Y Zhang et al.
NATURE CELL BIOLOGY (2003)
Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability
A Beugnet et al.
BIOCHEMICAL JOURNAL (2003)
A PI-3 kinase-dependent, Stat1-independent signaling pathway regulates interferon-stimulated monocyte adhesion
A Navarro et al.
JOURNAL OF LEUKOCYTE BIOLOGY (2003)
Development and characterisation of tetracycline-regulated phosphoinositide 3-kinase mutants: assessing the role of multiple phosphoinositide 3-kinases in chemokine signaling
AP Curnock et al.
JOURNAL OF IMMUNOLOGICAL METHODS (2003)
REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species
LW Ellisen et al.
MOLECULAR CELL (2002)
Regulation of hypoxia-inducible factor 1α expression and function by the mammalian target of rapamycin
CC Hudson et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
K Inoki et al.
NATURE CELL BIOLOGY (2002)
Persistent mitochondrial hyperpolarization, increased reactive oxygen intermediate production, and cytoplasmic alkalinization characterize altered IL-10 signaling in patients with systemic lupus erythematosus
P Gergely et al.
JOURNAL OF IMMUNOLOGY (2002)
The CD28 signaling pathway regulates glucose metabolism
KA Frauwirth et al.
IMMUNITY (2002)
Peroxisome proliferator-activated receptor-γ agonists prevent experimental autoimmune encephalomyelitis
DL Feinstein et al.
ANNALS OF NEUROLOGY (2002)
Intracellular sensing of amino acids in Xenopus laevis oocytes stimulates p70 S6 kinase in a target of rapamycin-dependent manner
GR Christie et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Peroxisome proliferator-activated receptor-gamma agonist 15-deoxy-Delta(12,14)-prostaglandin J(2) ameliorates experimental autoimmune encephalomyelitis
A Diab et al.
JOURNAL OF IMMUNOLOGY (2002)
Antagonistic roles for CTLA-4 and the mammalian target of rapamycin in the regulation of clonal anergy: Enhanced cell cycle progression promotes recall antigen responsiveness
TL Vanasek et al.
JOURNAL OF IMMUNOLOGY (2001)
A conserved family of prolyl-4-hydroxylases that modify HIF
RK Bruick et al.
SCIENCE (2001)
Recruitment times, proliferation, and apoptosis rates during the CD8+ T-Cell response to lymphocytic choriomeningitis virus
RJ De Boer et al.
JOURNAL OF VIROLOGY (2001)
Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells
TN Seagroves et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Critical requirement for the membrane-proximal cytosolic tyrosine residue for CD28-mediated costimulation in vivo
Y Harada et al.
JOURNAL OF IMMUNOLOGY (2001)
Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-gamma but not T(H)2 cytokines
LP Kane et al.
NATURE IMMUNOLOGY (2001)
Induction of IκBα expression as a mechanism contributing to the anti-inflammatory activities of peroxisome proliferator-activated receptor-α activators
P Delerive et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Promoter analysis of the mouse sterol regulatory element-binding protein-1c gene
M Amemiya-Kudo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
The CD28 and CTLA-4 receptors associate with the serine/threonine phosphatase PP2A
E Chuang et al.
IMMUNITY (2000)
Homeostasis-stimulated proliferation drives naive T cells to differentiate directly into memory T cells
BK Cho et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2000)
A novel transcription factor, T-bet, directs Th1 lineage commitment
SJ Szabo et al.
CELL (2000)
The PPARs: From orphan receptors to drug discovery
TM Willson et al.
JOURNAL OF MEDICINAL CHEMISTRY (2000)
Function of PI3Kγ in thymocyte development, T cell activation, and neutrophil migration
T Sasaki et al.
SCIENCE (2000)
The nuclear receptor PPARγ and immunoregulation:: PPARγ mediates inhibition of helper T cell responses
RB Clark et al.
JOURNAL OF IMMUNOLOGY (2000)
分享论文
