期刊
IMMUNOLOGICAL REVIEWS
卷 251, 期 -, 页码 160-176出版社
WILEY
DOI: 10.1111/imr.12023
关键词
fibroblastic reticular cell; lymphatic endothelial cell; blood endothelial cell; integrin alpha(+)(7) pericyte; T cell; dendritic cell; tolerance/suppression
类别
资金
- National Institutes of Health [R01 DK074500, P01 AI045757]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [P01AI045757] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK074500] Funding Source: NIH RePORTER
Secondary lymphoid organs (SLOs), including lymph nodes, Peyer's patches, and the spleen, have evolved to bring cells of the immune system together. In these collaborative environments, lymphocytes scan the surfaces of antigen-presenting cells for cognate antigens, while moving along stromal networks. The cell-cell interactions between stromal and hematopoietic cells in SLOs are therefore integral to the normal functioning of these tissues. Not only do stromal cells physically construct SLO architecture but they are essential for regulating hematopoietic populations within these domains. Stromal cells interact closely with lymphocytes and dendritic cells, providing scaffolds on which these cells migrate, and recruiting them into niches by secreting chemokines. Within lymph nodes, stromal cell-ensheathed conduit networks transport small antigens deep into the SLO parenchyma. More recently, stromal cells have been found to induce peripheral CD8(+) T-cell tolerance and control the extent to which newly activated T cells proliferate within lymph nodes. Thus, stromal-hematopoietic crosstalk has important consequences for regulating immune cell function within SLOs. In addition, stromal cell interactions with hematopoietic cells, other stroma, and the inflammatory milieu have profound effects on key stromal functions. Here, we examine ways in which these interactions within the lymph node environment influence the adaptive immune response.
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