4.6 Review

The fourth dimension in immunological space: how the struggle for nutrients selects high-affinity lymphocytes

期刊

IMMUNOLOGICAL REVIEWS
卷 249, 期 -, 页码 84-103

出版社

WILEY
DOI: 10.1111/j.1600-065X.2012.01156.x

关键词

clonal diversity; antigen receptor; apoptosis; glucose; Mcl-1; Noxa

向作者/读者索取更多资源

Lymphocyte activation via the antigen receptor is associated with radical shifts in metabolism and changes in requirements for nutrients and cytokines. Concomitantly, drastic changes occur in the expression of pro-and anti-apoptotic proteins that alter the sensitivity of lymphocytes to limiting concentrations of key survival factors. Antigen affinity is a primary determinant for the capacity of activated lymphocytes to access these vital resources. The shift in metabolic needs and the variable access to key survival factors is used by the immune system to eliminate activated low-affinity cells and to generate an optimal high-affinity response. In this review, we focus on the control of apoptosis regulators in activated lymphocytes by nutrients, cytokines, and costimulation. We propose that the struggle among individual clones that leads to the formation of high-affinity effector cell populations is in effect an invisible fourth signal required for effective immune responses.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据