期刊
IMMUNOLOGICAL REVIEWS
卷 240, 期 -, 页码 40-51出版社
WILEY
DOI: 10.1111/j.1600-065X.2010.01000.x
关键词
immunologic memory; T cells; B cells; plasma cells; analytic vaccinology
类别
资金
- Swiss National Science Foundation [101962, 131092, 126027]
- NIH [AI057266]
- German Research Foundation [Zi 1262/1-1]
Studies on immunologic memory in animal models and especially in the human system are instrumental to identify mechanisms and correlates of protection necessary for vaccine development. In this article, we provide an overview of the cellular basis of immunologic memory. We also describe experimental approaches based on high throughput cell cultures, which we have developed to interrogate human memory T cells, B cells, and plasma cells. We discuss how these approaches can provide new tools and information for vaccine design, in a process that we define as 'analytic vaccinology'.
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