期刊
IMMUNOLOGICAL REVIEWS
卷 243, 期 -, 页码 191-205出版社
WILEY
DOI: 10.1111/j.1600-065X.2011.01040.x
关键词
DAMPs; IL-1; adjuvant; sterile inflammation
类别
资金
- NIH
- AAF
- National Institute of Diabetes and Digestive and Kidney Diseases [5 P30 DK32520]
- Sanofi Aventis
- Grants-in-Aid for Scientific Research [23591468, 22890197] Funding Source: KAKEN
The immune system plays an essential role in protecting the host against infections and to accomplish this task has evolved mechanisms to recognize microbes and destroy them. In addition, it monitors the health of cells and responds to ones that have been injured and killed, even if this occurs under sterile conditions. This process is initiated when dying cells expose intracellular molecules that can be recognized by cells of the innate immune system. As a consequence of this recognition, dendritic cells are activated in ways that help to promote T-cell responses to antigens associated with the dying cells. In addition, macrophages are stimulated to produce the cytokine interleukin-1 that then acts on radioresistant parenchymal cells in the host in ways that drive a robust inflammatory response. In addition to dead cells, a number of other sterile particles and altered physiological states can similarly stimulate an inflammatory response and do so through common pathways involving the inflammasome and interleukin-1. These pathways underlie the pathogenesis of a number of diseases.
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