期刊
IMMUNOLOGICAL REVIEWS
卷 243, 期 -, 页码 152-162出版社
WILEY
DOI: 10.1111/j.1600-065X.2011.01043.x
关键词
NLRP3; inflammasome; caspase-1; sterile inflammation
类别
资金
- NIH [R01 AI087630, K08 AI067736]
- Dutch Kidney Foundation [C06.6023]
- Edward Mallinckrodt, Jr. Foundation
The NLRP3 inflammasome is activated in response to a variety of signals that are indicative of damage to the host including tissue damage, metabolic stress, and infection. Upon activation, the NLRP3 inflammasome serves as a platform for activation of the cysteine protease caspase-1, which leads to the processing and secretion of the proinflammatory cytokines interleukin-1 beta (IL-1 beta) and IL-18. Dysregulated NLRP3 inflammasome activation is associated with both heritable and acquired inflammatory diseases. Here, we review new insights into the mechanism of NLRP3 inflammasome activation and its role in disease pathogenesis.
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