期刊
IMMUNOLOGICAL REVIEWS
卷 245, 期 -, 页码 13-26出版社
WILEY
DOI: 10.1111/j.1600-065X.2011.01075.x
关键词
immune system ontogeny; Bacteroides fragilis; polysaccharide A (PSA); zwitterionic polysaccharides (ZPSs); host-microbe interactions
类别
资金
- National Institutes of Health (NIH) [F32 AI091104]
- Crohn's and Colitis Foundation of America
- Juvenile Diabetes Research Foundation
- NIH/NIAID [R21 AI090102, R01 AI089915]
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [T32HD055148] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R21AI090102, F32AI091104, R01AI089915] Funding Source: NIH RePORTER
Over the past several years, there have been remarkable advances in our understanding of how commensal organisms shape host immunity. Although the full cast of immunogenic bacteria and their immunomodulatory molecules remains to be elucidated, lessons learned from the interactions between bacterial zwitterionic polysaccharides (ZPSs) and the host immune system represent an integral step toward better understanding how the intestinal microbiota effect immunologic changes. Somewhat paradoxically, ZPSs, which are found in numerous commensal organisms, are able to elicit both proinflammatory and immunoregulatory responses; both these outcomes involve fine-tuning the balance between T-helper 17 cells and interleukin-10-producing regulatory T cells. In this review, we discuss the immunomodulatory effects of the archetypal ZPS, Bacteroides fragilis PSA. In addition, we highlight some of the opportunities and challenges in applying these lessons in clinical settings.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据