期刊
IMMUNOLOGICAL REVIEWS
卷 240, 期 -, 页码 25-39出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1600-065X.2010.00997.x
关键词
infectious diseases; T cells; natural killer T cells; antigen presentation; processing; cytotoxicity
类别
For many intracellular bacteria, both adaptively acquired and innately encoded effector T cells play a central role in the control, and in some cases, clearance of these pathogens. Through the rapid identification of those cells harboring intracellular bacteria, effector T cells have the capacity to both directly control the infection and shape the immune response to the pathogen. Here, we review the mechanisms by which effector T cells control intracellular infection and emphasize the means by which they recognize their targets. As will become evident, the diversity of both redundant and non-redundant effector mechanisms in conjunction with broad recognition of both protein and non-protein antigens allows for the identification of a broad array of bacterial pathogens and lessens the likelihood of immune evasion.
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