期刊
IMMUNOLOGICAL REVIEWS
卷 233, 期 -, 页码 286-300出版社
WILEY
DOI: 10.1111/j.0105-2896.2009.00849.x
关键词
NFAT; osteoporosis; osteoarthritis; rheumatoid arthritis; osteoclast; osteoblast
类别
资金
- Burroughs Wellcome Fund
- National Institute Of Arthritis And Musculoskeletal And Skin Diseases [K08AR054859]
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [K08AR054859] Funding Source: NIH RePORTER
Osteoporosis and arthritis are highly prevalent diseases and a significant cause of morbidity and mortality worldwide. These diseases result from aberrant tissue remodeling leading to weak, fracture-prone bones or painful, dysfunctional joints. The nuclear factor of activated T cells (NFAT) transcription factor family controls diverse biologic processes in vertebrates. Here, we review the scientific evidence that links NFAT-regulated gene transcription to bone and joint pathology. A particular emphasis is placed on the role of NFATs in bone resorption and formation by osteoclasts and osteoblasts, respectively. In addition, emerging data that connect NFATs with cartilage biology, angiogenesis, nociception, and neurogenic inflammation are explored. The goal of this article is to highlight the importance of tissue remodeling in musculoskeletal disease and situate NFAT-driven cellular responses within this context to inspire future research endeavors.
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