期刊
IMMUNOLOGICAL REVIEWS
卷 234, 期 -, 页码 268-281出版社
WILEY
DOI: 10.1111/j.0105-2896.2009.00874.x
关键词
CD103; dendritic cell; lung; intestine; antigen presentation
类别
资金
- DFG [SFB587-B3, SFB621-A1]
CD103 (alpha(E)) integrin expression distinguishes a population of dendritic cells (DCs) that can be found in many if not all lymphoid and non-lymphoid organs. CD103+ DCs display distinct functional activities. Migratory CD103+ DCs derived from skin, lung, and intestine efficiently present exogenous antigens in their corresponding draining lymph nodes to specific CD8+ T cells through a mechanism known as cross-presentation. On the T cells they prime, intestinal CD103+ DCs can drive the induction of the chemokine receptor CCR9 and alpha(4)beta(7) integrin, both known as gut-homing receptors. CD103+ DCs also contribute to control inflammatory responses and intestinal homeostasis by fostering the conversion of naive T cells into induced Foxp3+ regulatory T cells, a mechanism that relies on transforming growth factor-beta and retinoic acid signaling. This review discusses recent findings that identify murine CD103+ DCs as important regulators of the immune response.
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