期刊
IMMUNOLOGICAL REVIEWS
卷 236, 期 -, 页码 243-264出版社
WILEY
DOI: 10.1111/j.1600-065X.2010.00915.x
关键词
T cells; tolerance; amino acid metabolism; monocytes; macrophages; dendritic cells; nitric oxide
类别
资金
- Italian Ministry of Health
- Fondazione Cassa di Risparmio di Padova e Rovigo
- Italian Association for Cancer Research (AIRC)
- Association for International Cancer Research (AICR) [08-0518]
- Istituto Superiore Sanita -Alleanza Contro il Cancro [ACC8]
- Fondazione Italiana Sclerosi Multipla [2008/R/2]
The interaction between pathogenic microorganisms and their hosts is regulated by reciprocal survival strategies, including competition for essential nutrients. Though paradoxical, mammalian hosts have learned to take advantage of amino acid catabolism for controlling pathogen invasion and, at the same time, regulating their own immune responses. In this way, ancient catabolic enzymes have acquired novel functions and evolved into new structures with highly specialized functions, which go beyond the struggle for survival. In this review, we analyze the evidence supporting a critical role for the metabolism of various amino acids in regulating different steps of both innate and adaptive immunity.
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