期刊
IMMUNOLOGICAL REVIEWS
卷 238, 期 -, 页码 12-22出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1600-065X.2010.00956.x
关键词
lineage commitment; specification; thymus-settling progenitors; early thymic progenitors; Notch signal; transcription factors
类别
资金
- NIH [AI080091, AI059621, HL086900, RC1HL099758]
- Leukemia and Lymphoma Society
T cells originate from hematopoietic stem cells (HSCs) in the bone marrow but complete their development in the thymus. HSCs give rise to a variety of non-renewing hematopoietic progenitors, among which a rare subset migrates to the thymus via the bloodstream. The earliest T-cell progenitors identified in the thymus are not T-lineage restricted but possess the ability to give rise to cells of many different lineages. Alternative lineage potentials are gradually lost as progenitors progress toward later developmental stages. Here, we review the early developmental events that might be involved in T-cell lineage fate determination, including the properties of possible thymus-settling progenitors, their homing into the thymus, and their T-cell lineage specification and commitment.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据