期刊
IMMUNOLOGICAL REVIEWS
卷 238, 期 -, 页码 138-149出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1600-065X.2010.00953.x
关键词
Bcl11b; T cells; transcription factor; identity; natural killer; reprogramming; immunotherapy
类别
T-cell development primarily occurs in the thymus and involves in the interactions of many important transcription factors. Until recently, no single transcription factor has been identified to be essential for T-cell lineage commitment or maintenance of T-cell identity. Recent studies have now identified the zinc finger transcription factor Bcl11b to be essential for T-cell development and for maintenance of T-cell identity. Remarkably, T cells acquire NK cell properties upon Bcl11b deletion. These reprogrammed cells have unique properties in proliferation, cytokine dependency and killing target cells, and may therefore provide a new cell source for some cell-based therapies.
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