期刊
IMMUNOLOGICAL REVIEWS
卷 238, 期 -, 页码 182-194出版社
WILEY-BLACKWELL PUBLISHING, INC
DOI: 10.1111/j.1600-065X.2010.00958.x
关键词
ThPOK; thymocyte; T-cell development; CD4; lineage choice; gamma delta TCR
类别
资金
- NIH [AI068907, AI079247, P01CA06927]
The role of the zinc finger transcription factor ThPOK (T-helper-inducing POZ-Kruppel-like factor) in promoting commitment of alpha beta T cells to the CD4 lineage is now well established. New results indicate that ThPOK is also important for the development and/or acquisition of effector functions by other T cell subsets, including several not marked by CD4 expression, i.e. double-negative invariant natural killer T (iNKT) cells, gamma delta cells, and even memory CD8+ T cells. There is compelling evidence that ThPOK expression in most or all of these cases is dependent on T-cell receptor signaling and that differences in relative TCR signal strength/length may induce different levels of ThPOK expression. The developmental consequences of ThPOK expression vary according to cell type, which may partly reflect differences in ThPOK levels and/or in transcriptional networks between cell types.
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