期刊
IMMUNOLOGICAL REVIEWS
卷 236, 期 -, 页码 41-53出版社
WILEY-BLACKWELL PUBLISHING, INC
DOI: 10.1111/j.1600-065X.2010.00918.x
关键词
T cells; apoptosis; autophagy; cell activation; signaling proteins
类别
资金
- NIAID NIH HHS [R01 AI037988-15, R01 AI037988-14, R01 AI037988] Funding Source: Medline
Programmed cell death (PCD) occurs widely in species from every kingdom of life. It has been shown to be an integral aspect of development in multicellular organisms, and it is an essential component of the immune response to infectious agents. An analysis of the phylogenetic origin of PCD now shows that it evolved independently several times, and it is fundamental to basic cellular physiology. Undoubtedly, PCD pervades all life at every scale of analysis. These considerations provide a backdrop for understanding the complexity of intertwined, but independent, cell death programs that operate within the immune system. In particular, the contributions of apoptosis, autophagy, and necrosis in the resolution of an immune response are considered.
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