期刊
IMMUNOLOGICAL REVIEWS
卷 227, 期 -, 页码 87-94出版社
WILEY
DOI: 10.1111/j.1600-065X.2008.00726.x
关键词
innate immunity; Toll-like receptor; RIG-I-like receptor; pattern recognition receptors; viral immunity
类别
资金
- JDRF [24-2007-420]
- [T32 AI007163]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [T32AI007163] Funding Source: NIH RePORTER
Innate sensors of viral infection detect viral products and initiate the signal cascades that lead to the antiviral response. Several proteins have been identified to play a role in this process, mostly members of the Toll-like receptor and retinoic acid-inducible gene I-like receptor families. These receptors have been demonstrated to function in part by recognizing a diverse yet unique repertoire of nucleic acid substrates. Upon recognition of their ligands, these sensors activate distinct signaling pathways that lead to the secretion of type I interferon and inflammatory cytokines. It remains to be seen, however, if these sensors are redundant or whether each serves a unique function. In this work, we review the current knowledge of viral sensors, speculate on how they may function in vivo, and explore the potential reasons for their diversity.
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