期刊
IMMUNOLOGICAL REVIEWS
卷 222, 期 -, 页码 155-161出版社
BLACKWELL PUBLISHING
DOI: 10.1111/j.1600-065X.2008.00607.x
关键词
macrophages; cancer; inflammation; tumor promotion; surveillance
类别
资金
- Associazione Italiana per la Ricerca sul Cancro Funding Source: Custom
An intrinsic (oncogene-driven) pathway and an extrinsic (microenvironment-driven) pathway connect inflammatory reactions and cancer. M2-polarized tumor-associated macrophages and the related myeloid-derived suppressor cells are key prototypic components of smoldering inflammation driving neoplastic progression. However, mononuclear phagocytes can exert anti-tumor activity by killing tumor cells and eliciting tissue disruptive reactions (M1), a likely scenario in the early phases of carcinogenesis of immunogenic tumors and following therapeutic intervention. Shifting the macrophage balance represents a viable therapeutic target. Herein, the 'macrophage balance' is discussed in the context of the apparent paradox of tumor promotion by innate immunity-driven inflammation and the seemingly opposed tumor surveillance by adaptive immune responses.
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