期刊
IMMUNOLOGICAL REVIEWS
卷 226, 期 -, 页码 19-28出版社
WILEY
DOI: 10.1111/j.1600-065X.2008.00697.x
关键词
interleukin-2; effector T cells; regulatory T cells
类别
Interleukin-2 (IL-2) has multiple, sometimes opposing, functions during an inflammatory response. It is a potent inducer of T-cell proliferation and T-helper 1 (Th1) and Th2 effector T-cell differentiation and provides T cells with a long-lasting competitive advantage resulting in the optimal survival and function of memory cells. In a regulatory role, IL-2 is important for the development, survival, and function of regulatory T cells, it enhances Fas-mediated activation-induced cell death, and it inhibits the development of inflammatory Th17 cells. Thus, in its dual and contrasting functions, IL-2 contributes to both the induction and the termination of inflammatory immune responses.
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