期刊
IMMUNOLOGICAL REVIEWS
卷 225, 期 -, 页码 272-283出版社
WILEY
DOI: 10.1111/j.1600-065X.2008.00671.x
关键词
CD8(+) T cells; memory; malaria; sporozoite; liver; lymph node
类别
资金
- National Institutes of Health [AI44375]
- Malaria Research Institute
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI044375, R21AI044375] Funding Source: NIH RePORTER
Immunization with high doses of irradiated sporozoites delivered by the bites of infected mosquitoes has been shown to induce protective responses against malaria, mediated in part by CD8(+) T cells. In contrast, natural transmission involving low exposure to live sporozoite antigen fails to elicit strong immunity. In this review, we examine how irradiated sporozoite immunization breaks the natural host-parasite interaction and induces protective CD8(+) T cells. Upon biting, the malaria-infected mosquitoes deposit parasites in the skin, many of which eventually exit to the bloodstream and infect hepatocytes. However, certain antigens, including the circumsporozoite (CS) protein, remain in the skin and are presented in the draining lymph node. These antigens prime specific CD8(+) T cells, which migrate to the liver where they eliminate parasitized hepatocytes. We discuss the relevance of the different tissue compartments involved in the induction and effector phases of this response, as well as the cellular requirements for priming and memory development of CD8(+) T cells, which include a complete dependence on dendritic cells and a near absolute need for CD4(+) T-cell help. Finally, we discuss the impact of the immunodominant CS protein on this protection and the implications of these findings for vaccine design.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据