期刊
IMMUNOLOGICAL REVIEWS
卷 222, 期 -, 页码 145-154出版社
WILEY
DOI: 10.1111/j.1600-065X.2008.00600.x
关键词
cancer; humoral immunity; inflammation; innate immunity; leukocytes; adaptive immunity
类别
资金
- NCI NIH HHS [P01 CA072006-06A29002, CA72006, R01 CA094168-05, R01 CA098075, CA94168, R01 CA098075-05, R01 CA094168, P01 CA072006, CA098075] Funding Source: Medline
- NCRR NIH HHS [U54 RR020843, U54 RR020843-045942] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [P01CA072006, R01CA094168, R01CA098075] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [U54RR020843] Funding Source: NIH RePORTER
Tumor-associated immune responses assert varied responses toward developing neoplasms that can either act to eradicate malignant cells via engagement of potent cytotoxic programs or alternatively enhance tumor growth through release of multifunctional pro-tumor mediators. Seemingly paradoxical, these disparate activities reflect a continuum of polarization (or activation) states possible for distinct leukocyte subsets that demonstrate tissue, organ, and tumor selectivity. Herein, we review clinical and experimental studies investigating cellular and molecular mechanisms utilized by neoplastic tissues to alternatively polarize immune responses that favor either pro- or anti-tumor immunity.
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