期刊
IMMUNOLOGICAL REVIEWS
卷 221, 期 -, 页码 182-187出版社
WILEY
DOI: 10.1111/j.1600-065X.2008.00588.x
关键词
Tcell; dendritic cell; imaging; lymph node
类别
T lymphocytes receive activation signals during their encounters with antigen-bearing dendritic cells (DCs) in secondary lymphoid organs. With the recent application of two-photon imaging to visualize immune responses as they happen, the dynamics of T cell-DC interactions have been dissected in several mouse models. As we are integrating the results of these new studies, we are learning that the dynamics of T cell-DC interactions are regulated by multiple immunological parameters and, most importantly, that the spatiotemporal characteristics of these cell-cell contacts encode part of the T-cell fate.
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