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Interleukin-10 inhibits osteoclastogenesis by reducing NFATcI expression and preventing its translocation to the nucleus
Kathryn E. Evans et al.
BMC CELL BIOLOGY (2007)
IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo
Virginie Carriere et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Th1 immune response promotes severe bone resorption caused by Porphyromonas gingivalis
Philip Stashenko et al.
AMERICAN JOURNAL OF PATHOLOGY (2007)
IFN-gamma stimulates osteoclast formation and bone loss in vivo via antigen-driven T cell activation
Yuhao Gao et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
The adaptor Act1 is required for interleukin 17-dependent signaling associated with autoimmune and inflammatory disease
Youcun Qian et al.
NATURE IMMUNOLOGY (2007)
Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction
Kojiro Sato et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2006)
Impaired skeletal development in interleukin-6-transgenic mice - A model for the impact of chronic inflammation on the growing skeletal system
Fabrizio De Benedetti et al.
ARTHRITIS AND RHEUMATISM (2006)
IL-18 induces apoptosis of adherent bone marrow cells in TNF-α mediated osteoclast formation in synergy with IL-12
Hideki Kitaura et al.
IMMUNOLOGY LETTERS (2006)
Function of interleukin-20 as a proinflammatory molecule in rheumatoid and experimental arthritis
Yu-Hsiang Hsu et al.
ARTHRITIS AND RHEUMATISM (2006)
Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate
R. N. Maini et al.
ARTHRITIS AND RHEUMATISM (2006)
The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design
Thomas A. Waldmann
NATURE REVIEWS IMMUNOLOGY (2006)
Inhibition of IKK activation, through sequestering NEMO, blocks PMMA-induced osteoclastogenesis and calvarial inflammatory osteolysis
John C. Clohisy et al.
JOURNAL OF ORTHOPAEDIC RESEARCH (2006)
RANKL stimulates inducible nitric-oxide synthase expression and nitric oxide production in developing osteoclasts -: An autocrine negative feedback mechanism triggered by RANKL-induced interferon-β via NF-κB that restrains osteoclastogenesis and bone resorption
Hong Zheng et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Interleukin-7 influences osteoclast function in vivo but is not a critical factor in ovariectomy-induced bone loss
SK Lee et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2006)
Peripheral blood T lymphocytes from patients with early rheumatoid arthritis express RANKL and interleukin-15 on the cell surface and promote osteoclastogenesis in autologous monocytes
ME Miranda-Carús et al.
ARTHRITIS AND RHEUMATISM (2006)
Id helix-loop-helix proteins negatively regulate TRANCE-mediated osteoclast differentiation
J Lee et al.
BLOOD (2006)
IL-32, a proinflammatory cytokine in rheumatoid arthritis
LAB Joosten et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Inhibition of hormone and cytokine-stimulated osteoclastogenesis and bone resorption by interleukin-4 and interleukin-13 is associated with increased osteoprotegerin and decreased RANKL and RANK in a STAT6-dependent pathway
P Palmqvist et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
IL-13 signaling through the IL-13 alpha 2 receptor is involved in induction of TGF-beta 1 production and fibrosis
S Fichtner-Feigl et al.
NATURE MEDICINE (2006)
Fos/AP-1 proteins in bone and the immune system
EF Wagner et al.
IMMUNOLOGICAL REVIEWS (2005)
Stromal cells and osteoclasts are responsible for exacerbated collagen-induced arthritis in interferon-β-deficient mice
AP Treschow et al.
ARTHRITIS AND RHEUMATISM (2005)
Tumor-derived interleukin-8 stimulates osteolysis independent of the receptor activator of nuclear factor-κB ligand pathway
MS Bendre et al.
CANCER RESEARCH (2005)
M-CSF mediates TNF-induced inflammatory osteolysis
H Kitaura et al.
JOURNAL OF CLINICAL INVESTIGATION (2005)
An IL-7-dependent rebound in thymic T cell output contributes to the bone loss induced by estrogen deficiency
MR Ryan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines
J Schmitz et al.
IMMUNITY (2005)
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
H Park et al.
NATURE IMMUNOLOGY (2005)
Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
LE Harrington et al.
NATURE IMMUNOLOGY (2005)
Interleukin-11 receptor signaling is required for normal bone remodeling
NA Sims et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2005)
NF-κB-inducing kinase controls lymphocyte and osteoclast activities in inflammatory arthritis
K Aya et al.
JOURNAL OF CLINICAL INVESTIGATION (2005)
IκB kinase (IKK)β, but not IKKα, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss
MG Ruocco et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2005)
Stromal cell-derived factor-1 binding to its chemokine receptor CXCR4 on precursor cells promotes the chemotactic recruitment, development and survival of human osteoclasts
LM Wright et al.
BONE (2005)
Mechanisms of type-I- and type-II-interferon-mediated signalling
LC Platanias
NATURE REVIEWS IMMUNOLOGY (2005)
Interleukin-4 inhibits RANKL-induced expression of NFATc1 and c-Fos: A possible mechanism for downregulation of osteoclastogenesis
SGK Mohamed et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
Expression of interleukin-22 in rheumatoid arthritis - Potential role as a proinflammatory cytokine
H Ikeuchi et al.
ARTHRITIS AND RHEUMATISM (2005)
C5a negatively regulates Toll-like receptor 4-induced immune responses
H Hawlisch et al.
IMMUNITY (2005)
Cytokines link osteoblasts and inflammation:: microarray analysis of interleukin-17-and TNF-α-induced genes in bone cells
F Shen et al.
JOURNAL OF LEUKOCYTE BIOLOGY (2005)
IL-1 mediates TNF-induced osteoclastogenesis
S Wei et al.
JOURNAL OF CLINICAL INVESTIGATION (2005)
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
CL Langrish et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2005)
CXCL12 chemokine up-regulates bone resorption and MMP-9 release by human osteoclasts: CXCL12 levels are increased in synovial and bone tissue of rheumatoid arthritis patients
F Grassi et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2004)
The immunomodulatory adapter proteins DAP12 and Fc receptor γ-chain (FcRγ) regulate development of functional osteoclasts through the Syk tyrosine kinase
A Mócsai et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis
T Koga et al.
NATURE (2004)
Neuropoietin, a new IL-6-related cytokine signaling through the ciliary neurotrophic factor receptor
D Derouet et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Interleukin (IL)-17 enhances tumor necrosis factor-α-stimulated IL-6 synthesis via p38 mitogen-activated protein kinase in osteoblasts
H Tokuda et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2004)
The IκB kinase (IKK) inhibitor, NEMO-binding domain peptide, blocks osteoclastogenesis and bone erosion in inflammatory arthritis
S Dai et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Lipopolysaccharide stimulates expression of osteoprotegerin and receptor activator of NF-kappa B ligand in periodontal ligament fibroblasts through the induction of interleukin-1 beta and tumor necrosis factor-alpha
N Wada et al.
BONE (2004)
Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1
DJ Ceradini et al.
NATURE MEDICINE (2004)
The interleukin-10 knockout mouse is highly susceptible to Porphyromonas gingivalis-induced alveolar bone loss
H Sasaki et al.
JOURNAL OF PERIODONTAL RESEARCH (2004)
Interferons, interferon-like cytokines, and their receptors
S Pestka et al.
IMMUNOLOGICAL REVIEWS (2004)
Interleukin (IL) 18 stimulates osteoclast formation through synovial T cells in rheumatoid arthritis:: comparison with IL1β and tumour necrosis factor α
SM Dai et al.
ANNALS OF THE RHEUMATIC DISEASES (2004)
Human interleukin-1-induced murine osteoclastogenesis is dependent on RANKL, but independent of TNF-α
T Ma et al.
CYTOKINE (2004)
Inhibition of RANKL-induced osteoclast formation in mouse bone marrow cells by IL-12:: involvement of IFN-γ possibly induced from non-T cell population
N Nagata et al.
BONE (2003)
The IκB function of NF-κB2 p100 controls stimulated osteoclastogenesis
DV Novack et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2003)
Stromal cell-derived factor-1 (SDF-1) recruits osteoclast precursors by inducing chemotaxis, matrix metalloproteinase-9 (MMP-9) activity, and collagen transmigration
XF Yu et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2003)
IL-4 suppresses osteoclast development and mature osteoclast function by a STAT6-dependent mechanism: irreversible inhibition of the differentiation program activated by RANKL
JL Moreno et al.
BLOOD (2003)
Interleukin-7 is a direct inhibitor of in vitro osteoclastogenesis
SK Lee et al.
ENDOCRINOLOGY (2003)
Interleukin-8 stimulation of osteoclastogenesis and bone resorption is a mechanism for the increased osteolysis of metastatic bone disease
MS Bendre et al.
BONE (2003)
Bone malformations in interleukin-18 Transgenic mice
Y Kawase et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2003)
Cytokine regulation of IL-13Rα2 and IL-13Rα1 in vivo and in vitro
T Zheng et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2003)
Regulation and function of the interleukin 13 receptor α 2 during a T helper cell type 2-dominant immune response
MG Chiaramonte et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2003)
Interleukin-12 and the regulation of innate resistance and adaptive immunity
G Trinchieri
NATURE REVIEWS IMMUNOLOGY (2003)
IL-7 induces bone loss in vivo by induction of receptor activator of nuclear factor κB ligand and tumor necrosis factor a from T cells
G Toraldo et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
The structure and binding mode of interleukin-18
Z Kato et al.
NATURE STRUCTURAL BIOLOGY (2003)
Collagen-induced arthritis is exacerbated in IL-10-deficient mice
A Finnegan et al.
ARTHRITIS RESEARCH & THERAPY (2003)
Interleukin-6 and interleukin-11 support human osteoclast formation by a RANKL-independent mechanism
O Kudo et al.
BONE (2003)
Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts
H Takayanagi et al.
DEVELOPMENTAL CELL (2002)
Suppression of bone resorption by madindoline A, a novel nonpeptide antagonist to gp130
M Hayashi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Long-term safety and maintenance of clinical improvement following treatment with anakinra (recombinant human interleukin-1 receptor antagonist) in patients with rheumatoid arthritis
G Nuki et al.
ARTHRITIS AND RHEUMATISM (2002)
IL-15Rα recycles and presents IL-15 in trans to neighboring cells
S Dubois et al.
IMMUNITY (2002)
Interleukin 17 synergises with tumour necrosis factor α to induce cartilage destruction in vitro
RL van Bezooijen et al.
ANNALS OF THE RHEUMATIC DISEASES (2002)
SHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclasts
S Takeshita et al.
NATURE MEDICINE (2002)
NF-κB p50 and p52 expression is not required for RANK-expressing osteoclast progenitor formation but is essential for RANK- and cytokine-mediated osteoclastogenesis
LP Xing et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2002)
Characterization of the bone-resorptive effect of interleukin-11 in cultured mouse calvarial bones
J Ahlen et al.
BONE (2002)
Interleukin-18 and interleukin-12 synergistically inhibit osteoclastic bone-resorbing activity
N Yamada et al.
BONE (2002)
RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-β
H Takayanagi et al.
NATURE (2002)
Cytokine signaling in 2002: New surprises in the Jak/Stat pathway
JJ O'Shea et al.
CELL (2002)
Interleukin-4 reversibly inhibits osteoclastogenesis via inhibition of NF-κB and mitogen-activated protein kinase signaling
S Wei et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Signaling crosstalk between RANKL and interferons in osteoclast differentiation
Hiroshi Takayanagi et al.
ARTHRITIS RESEARCH & THERAPY (2002)
Characterization of interferon gamma receptors on osteoclasts: Effect of interferon gamma on osteoclastic superoxide generation
S Yang et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2002)
Treatment of rheumatoid arthritis with anakinra, a recombinant human interleukin-1 receptor antagonist, in combination with methotrexate - Results of a twenty-four-week, multicenter, randomized, double-blind, placebo-controlled trial
S Cohen et al.
ARTHRITIS AND RHEUMATISM (2002)
Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects
XM Dai et al.
BLOOD (2002)
IL-10-deficient B10.Q mice develop more severe collagen-induced arthritis, but are protected from arthritis induced with anti-type II collagen antibodies
ÅCM Johansson et al.
JOURNAL OF IMMUNOLOGY (2001)
IL-4 abrogates osteoclastogenesis through STAT6-dependent inhibition of NF-κB
Y Abu-Amer
JOURNAL OF CLINICAL INVESTIGATION (2001)
Effect of interleukin-17 on nitric oxide production and osteoclastic bone resorption:: Is there dependency on nuclear factor-κB and receptor activator of nuclear factor κB (RANK)/RANK ligand signaling?
RL van Bezooijen et al.
BONE (2001)
IL-4 inhibits osteoclast formation through a direct action on osteoclast precursors via peroxisome proliferator-activated receptor γ1
AC Bendixen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Tumor necrosis factor-α (TNF) stimulates RANKL-induced osteoclastogenesis via coupling of TNF type 1 receptor and RANK signaling pathways
YH Zhang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Interferon-gamma down-regulates gene expression of cathepsin K in osteoclasts and inhibits osteoclast formation
S Kamolmatyakul et al.
JOURNAL OF DENTAL RESEARCH (2001)
The inhibitory effect of interleukin-10 on mouse osteoclast formation involves novel tyrosine-phosphorylated proteins
MH Hong et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2000)
T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-γ
H Takayanagi et al.
NATURE (2000)
Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
B Oppmann et al.
IMMUNITY (2000)
Interferon-γ directly inhibits TRANCE-induced osteoclastogenesis
SW Fox et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)
CLF associates with CLC to form a functional heteromeric ligand for the CNTF receptor complex
GCA Elson et al.
NATURE NEUROSCIENCE (2000)
Receptor subunit-specific action of oncostatin M in hepatic cells and its modulation by leukemia inhibitory factor
YP Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Receptor recognition by gp130 cytokines
J Bravo et al.
EMBO JOURNAL (2000)
Stimulation of osteoclast differentiation in vitro by mouse oncostatin M, leukaemia inhibitory factor, cardiotrophin-1 and interleukin 6: Synergy with dexamethasone
CD Richards et al.
CYTOKINE (2000)
IL-4 gene therapy for collagen arthritis suppresses synovial IL-17 and osteoprotegerin ligand and prevents bone erosion
E Lubberts et al.
JOURNAL OF CLINICAL INVESTIGATION (2000)
T1/ST2-deficient mice demonstrate the importance of T1/ST2 in developing primary T helper cell type 2 responses
MJ Townsend et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2000)
RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism
J Li et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in interleukin 1 receptor antagonist-deficient mice
R Horai et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2000)
Tumor necrosis factor α stimulates osteoclast differentiation by a mechanism independent of the ODF/RANKL-RANK interaction
K Kobayashi et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2000)
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