期刊
IMMUNOLOGICAL INVESTIGATIONS
卷 41, 期 6-7, 页码 711-721出版社
TAYLOR & FRANCIS INC
DOI: 10.3109/08820139.2012.673670
关键词
Breast cancer relapse; myeloid derived suppressor cells; tumor immunoediting
类别
资金
- Virginia's Commonwealth Health Research Board
- VCU Massey Cancer Center
- Commonwealth Foundation for Cancer Research
Myeloid-derived suppressor cells (MDSCs) were initially reported as suppressor of the adaptive immune responses against cancer and other diseases. However, emerging evidence suggest that MDSCs may also support anti-tumor immune responses under certain conditions or may inhibit tumor growth. In the present mini-review, we suggest that such opposing functions of MDSCs are due to phenotypic plasticity of the myeloid cells, allowing them to produce a diverse form of morphology, physiological state, and function in response to environmental conditions. Therefore, they can be manipulated by means of immune modulators to overcome their immune suppressive function.
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