期刊
IMMUNOLOGICAL INVESTIGATIONS
卷 39, 期 4-5, 页码 449-467出版社
TAYLOR & FRANCIS INC
DOI: 10.3109/08820130903563998
关键词
heat-labile enterotoxins; adjuvants; vaccines; gangliosides; toll-like receptors; inflammation
类别
资金
- U.S. Public Health Service [DE015254, DE017138]
- NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH [R01DE015254, R01DE017138] Funding Source: NIH RePORTER
Escherichia coli and Vibrio cholerae produce structurally related AB(5)-type heat-labile enterotoxins, which are classified into two major types. The Type I subfamily includes cholera toxin and E. coli LT-I, whereas the Type II subfamily comprises LT-IIa and LT-IIb. In addition to their roles in microbial pathogenesis, the enterotoxins are widely and intensively studied for their exceptionally strong adjuvant and immunomodulatory activities, which are not necessarily dependent upon their abilities to elevate intracellular cAMP levels. Despite general structural similarities, these molecules, in intact or derivative form, display notable differences in their interactions with gangliosides or Toll-like receptors. This divergence results in differential immune response outcomes, the underlying mechanisms of which remain largely uncharacterized. Whereas the study of these molecules has been pivotal in understanding basic mechanisms of immune regulation, a formidable challenge is to dissociate toxicity from useful properties that can be exploited in vaccine development or for the treatment of autoimmune inflammatory diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据