期刊
IMMUNOLOGICAL INVESTIGATIONS
卷 40, 期 2, 页码 197-205出版社
INFORMA HEALTHCARE
DOI: 10.3109/08820139.2010.532267
关键词
Advanced glycation end-products; Alzheimer's disease; Immunohistochemistry; Multiple sclerosis; RAGE
类别
资金
- Jog for the Jake
This pilot study used immunohistochemical techniques to investigate the advanced glycation end-product (AGE) Nepsilon-(carboxymethyl)lysine (CML) and its receptor (RAGE) in the brains of multiple sclerosis (MS) patients, comparing them with the brains of patients with Alzheimer's disease (AD) (positive controls) and with age-matched control subjects (negative controls). Postmortem slides derived from the hippocampi of MS patients, AD patients, and controls were stained with monoclonal antibodies for CML and human RAGE. Results showed increased AGE and RAGE immunostaining in the hippocampi of MS patients, similar to AD patients.
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