期刊
IMMUNOLOGIC RESEARCH
卷 58, 期 2-3, 页码 387-393出版社
HUMANA PRESS INC
DOI: 10.1007/s12026-014-8492-5
关键词
Leukotriene; Pulmonary arterial hypertension; Vascular remodeling; Inflammation; 5-Lipoxygenase
类别
资金
- NHLBI NIH HHS [P01 HL108797, R01 HL095686, R01 HL082662] Funding Source: Medline
Leukotrienes (LTs) are lipid mediators derived from the 5-lipoxygenase (5-LO) pathway of arachidonic acid metabolism and are markers and mediators of pulmonary inflammation. Research over the past two decades has established that LTs modulate inflammation in pulmonary arterial hypertension (PAH). The purpose of this review was to summarize the current knowledge of LTs in the pathophysiology of PAH and to highlight a recent study that advances our understanding of how leukotriene B-4 (LTB4) specifically contributes to pulmonary vascular remodeling. The results of these studies suggest that pharmacological inhibition of LT pathways, especially LTB4, has high potential for the treatment of PAH.
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