期刊
IMMUNOLOGIC RESEARCH
卷 51, 期 1, 页码 5-14出版社
HUMANA PRESS INC
DOI: 10.1007/s12026-011-8209-y
关键词
Cytokines; Cytokine receptor; Structure; IL-12; IL-23; IL-27; IL-35; gp130; IL-12R beta 1; IL-12R beta 2; IL-23R; WSX-1
类别
资金
- NIH [F32 AI084330, AI091977]
- American Asthma Foundation-Strategic Program for Asthma Research (SPAR) [10-0128]
- NCI Comprehensive Cancer Center [CA21765]
- American Lebanese Syrian Associated Charities
Production of cytokines by immune cells in response to stimuli and the binding of cytokines to specific receptors on target cells is a central feature of the immune response. The IL-12 cytokine family is particularly influential in determining the fate of T cells and is characterized by the sharing of cytokine and receptor subunits. A thorough understanding of the molecular interactions within this family will be a key to the development of therapeutic inhibitors or enhancers of IL-12 family function. While the current structural and molecular data for IL-12 family members is limited, there is ample information on the structurally related IL-6 cytokine family. This review will summarize the current structural and mutagenesis data within the IL-12 family and will attempt to utilize similarities between the IL-6 and IL-12 families to understand molecular interactions between IL-12 family subunits and with receptor components.
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