期刊
IMMUNOLOGIC RESEARCH
卷 50, 期 2-3, 页码 188-194出版社
HUMANA PRESS INC
DOI: 10.1007/s12026-011-8222-1
关键词
Autoimmunity; Human; Fibrosis; IL-13; CD8(+) T cells; GATA-3
类别
资金
- Scleroderma Foundation
Systemic sclerosis (SSc) is a progressive and highly debilitating autoimmune disorder characterized by inflammation, fibrosis, and vascular damage of the connective tissue. T cell-derived cytokines have been implicated in the induction of fibrosis. We found that high levels of the profibrotic type-2 cytokine IL-13 are produced by peripheral blood effector CD8(+) T cells from SSc patients compared to normal controls. This abnormality correlates with increased expression of the transcription factor GATA-3 and the extent of skin fibrosis. Together, the data provide new insights into SSc pathogenesis and identify a specific T cell phenotype that can be used as a biomarker of immune dysfunction in patients with SSc and as a novel therapeutic target for this currently incurable disease.
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