期刊
IMMUNOLOGIC RESEARCH
卷 43, 期 1-3, 页码 198-209出版社
HUMANA PRESS INC
DOI: 10.1007/s12026-008-8071-8
关键词
NADPH oxidase; Nox; Dual oxidase; Pyocyanin; Pseudomonas aeruginosa; Cystic fibrosis; Airway epithelium; Hydrogen peroxide; Oxidative stress
类别
资金
- Intramural NIH HHS [ZIA AI000614-19] Funding Source: Medline
The importance of reactive oxygen species-dependent microbial killing by the phagocytic cell NADPH oxidase has been appreciated for some time, although only recently has an appreciation developed for the partnership of lactoperoxidase with related dual oxidases (Duox) within secretions of the airway surface layer. This system produces mild oxidants designed for extracellular killing that are effective against several airway pathogens, including Staphylococcus aureus, Burkholderia cepacia, and Pseudomonas aeruginosa. Establishment of chronic pseudomonas infections involves adaptations to resist oxidant-dependent killing by expression of a redox-active virulence factor, pyocyanin, that competitively inhibits epithelial Duox activity by consuming intracellular NADPH and producing superoxide, thereby inflicting oxidative stress on the host.
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