期刊
IMMUNOLOGIC RESEARCH
卷 42, 期 1-3, 页码 132-144出版社
HUMANA PRESS INC
DOI: 10.1007/s12026-008-8047-8
关键词
T lymphocyte; Signaling; Integrins; Adapters
类别
Integrins are cell surface heterodimers that bind adhesion molecules expressed on other cells or in the extracellular matrix. Integrin-mediated interactions are critical for T cell development in the thymus, migration of T cells in the periphery, and induction of T cell effector functions. In resting T cells, integrins are maintained in a low affinity state. Engagement of the T cell receptor or chemokine receptors increases integrin affinity, enabling integrins to bind their ligands and initiate a signaling cascade resulting in altered cell morphology and motility. Our laboratory is interested how adapter proteins, mediators of intracellular signal transduction, regulate both signals from the T cell receptor to integrins (inside-out signaling) and (outside-in) signals from integrins into the cell.
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