期刊
IMMUNOGENETICS
卷 66, 期 11, 页码 597-611出版社
SPRINGER
DOI: 10.1007/s00251-014-0794-1
关键词
KIR; NK cells; HLA class I; Immune diversity; Maori; Polynesian
资金
- U.S. National Institutes of Health [AI17892, GM109030]
- Medical Research Council of the UK
- Victoria University of Wellington, NZ
- Ministry of Higher Education, Malaysia
HLA class I molecules and killer cell immunoglobulin-like receptors (KIR) form a diverse system of ligands and receptors that individualize human immune systems in ways that improve the survival of individuals and populations. Human settlement of Oceania by island-hopping East and Southeast Asian migrants started similar to 3,500 years ago. Subsequently, New Zealand was reached similar to 750 years ago by ancestral MAori. To examine how this history impacted KIR and HLA diversity, and their functional interaction, we defined at high resolution the allelic and haplotype diversity of the 13 expressed KIR genes in 49 MAori and 34 Polynesians. Eighty KIR variants, including four 'new' alleles, were defined, as were 35 centromeric and 22 telomeric KIR region haplotypes, which combine to give > 50 full-length KIR haplotypes. Two new and divergent variant KIR form part of a telomeric KIR haplotype, which appears derived from Papua New Guinea and was probably obtained by the Asian migrants en route to Polynesia. MAori and Polynesian KIR are very similar, but differ significantly from African, European, Japanese, and Amerindian KIR. MAori and Polynesians have high KIR haplotype diversity with corresponding allotype diversity being maintained throughout the KIR locus. Within the population, each individual has a unique combination of HLA class I and KIR. Characterizing MAori and Polynesians is a paucity of HLA-B allotypes recognized by KIR. Compensating for this deficiency are high frequencies (> 50 %) of HLA-A allotypes recognized by KIR. These HLA-A allotypes are ones that modern humans likely acquired from archaic humans at a much earlier time.
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