期刊
IMMUNOGENETICS
卷 61, 期 2, 页码 111-118出版社
SPRINGER
DOI: 10.1007/s00251-008-0347-6
关键词
Marsupial; MHC Class II; Tammar wallaby; MHC-linked microsatellite; Genetic variation
资金
- Australian Research Council Discovery
- University of Sydney Postgraduate Award
- Wellcome Trust
High levels of MHC diversity are crucial for immunological fitness of populations, with island populations particularly susceptible to loss of genetic diversity. In this study, the level of MHC class II DBB diversity was examined in tammar wallabies (Macropus eugenii) from Kangaroo Island by genotyping class II-linked microsatellite loci and sequencing of DBB genes. Here we show that the tammar wallaby has at least four expressed MHC class II DBB loci and extensive genetic variation in the peptide-binding region of the DBB genes. These results contradict early studies which suggested that wallabies lacked MHC class II diversity and demonstrate that, in spite of the long-term isolation on an offshore island, this population of wallabies has a high level of DBB diversity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据